FAQ

NAD biosynthetic process

Known as: NAD formation, oxidized nicotinamide adenine dinucleotide biosynthesis, oxidized nicotinamide adenine dinucleotide biosynthetic process 
The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1966-2018
0102019662018

Papers overview

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Highly Cited
2011
Highly Cited
2011
Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation.
NAD is a vital redox carrier, and its degradation is a key element of important regulatory pathways. NAD-mediated functions are… (More)
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Highly Cited
2011
Highly Cited
2011
An integrated approach to characterize genetic interaction networks in yeast metabolism
Although experimental and theoretical efforts have been applied to globally map genetic interactions, we still do not understand… (More)
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Highly Cited
2009
Highly Cited
2009
The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies.
APO866 inhibits nicotinamide phosphoribosyltransferase (NMPRTase), a key enzyme involved in nicotinamide adenine dinucleotide… (More)
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Highly Cited
2008
Highly Cited
2008
Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase/Visfatin Enzymatic Activity Identifies a New Inflammatory Pathway Linked to NAD
Nicotinamide phosphoribosyltransferase (NAMPT), also known as visfatin, is the rate-limiting enzyme in the salvage pathway of NAD… (More)
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Highly Cited
2008
Highly Cited
2008
Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice.
The Sir2 (silent information regulator 2) family of NAD-dependent deacetylases regulates aging and longevity across a wide… (More)
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Highly Cited
2007
Highly Cited
2007
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme.
Intracellular nicotinamide phosphoribosyltransferase (iNampt) is an essential enzyme in the NAD biosynthetic pathway. An… (More)
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Highly Cited
2004
Highly Cited
2004
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration.
Axonal degeneration is an active program of self-destruction that is observed in many physiological and pathological settings. In… (More)
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Highly Cited
2004
Highly Cited
2004
The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells.
Recent studies have revealed new roles for NAD and its derivatives in transcriptional regulation. The evolutionarily conserved… (More)
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Highly Cited
2002
Highly Cited
2002
Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis.
The murine homologue of the previously identified human "pre-B-cell colony-enhancing factor" (PBEF) gene coding for a putative… (More)
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Highly Cited
1996
Highly Cited
1996
Role of NAD in regulating the adhE gene of Escherichia coli.
The fermentative alcohol dehydrogenase of Escherichia coli is encoded by the adhE gene, which is induced under anaerobic… (More)
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