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N3-methyladenine

National Institutes of Health

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Broader (1)

Adenine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
N3-Methyladenine Induces Early Poly(ADP-Ribosylation), Reduction of Nuclear Factor-κB DNA Binding Ability, and Nuclear Up-Regulation of Telomerase Activity
Methylation of N3-adenine represents a novel pharmacological strategy for the treatment of resistant tumors. However, little is… 
2002
2002
Influences of Base Excision Repair Defects on the Lethality and Mutagenicity Induced by Me-lex, a Sequence-selective N3-Adenine Methylating Agent*
Due to its minor groove selectivity, Me-lex preferentially generates N3-methyladenine (3-MeA) adducts in double-stranded DNA. We… 
2001
2001
Evidence in Escherichia coli that N3-methyladenine lesions induced by a minor groove binding methyl sulfonate ester can be processed by both base and nucleotide excision repair.
It has been previously reported that a neutral DNA equilibrium binding agent based on an N-methylpyrrolecarboxamide dipeptide… 
Highly Cited
1999
Highly Cited
1999
mRNA cap recognition: dominant role of enhanced stacking interactions between methylated bases and protein aromatic side chains.
We have determined, by high resolution x-ray analysis, 10 structures comprising the mRNA cap-specific methyltransferase VP39 or… 
1996
1996
The in vitro methylation of DNA by a minor groove binding methyl sulfonate ester.
The preparation of sequence and groove specific DNA methylating agents based on N-methylpyrrolecarboxamide subunits appended with… 
1995
1995
DNA methylation by tert-butyl hydroperoxide-iron (II).
1994
1994
3T3 NIH murine fibroblasts and B78 murine melanoma cells expressing the Escherichia coli N3-methyladenine-DNA glycosylase I do not become resistant to alkylating agents.
The role of alkylation of the N3 position of adenine in the cytotoxicity of alkylating agents in mammalian cells is still… 
Highly Cited
1993
Highly Cited
1993
Groove- and sequence-selective alkylation of DNA by sulfonate esters tethered to lexitropsins.
A series of sulfonate esters that are attached to a noncationic minor-groove-binding N-methylpyrrole dipeptide (Lex) related to… 
1984
1984
Relationship of methyl purines produced by MNNG in adenovirus 5 DNA to viral inactivation in repair-deficient (Mer-) human tumor cell strains.
1980
1980
In vivo replication of hepatic deoxyribonucleic acid of rats treated with dimethylnitrosamine: presence of dimethylnitrosamine-induced O6-methylguanine, N7-methylguanine, and N3-methyladenine in the…
Experiments were designed to determine whether some chemical lesions such as O6-methylguanine, N7-methylguanine, and N3… 
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