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N2-ethyl-2'-deoxyguanosine

Known as: N(2)-ethyl-2'-deoxyguanosine, N2-ethyl-dG 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Deoxyguanosine
analogs & derivatives

Papers overview

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2012
2012
Detection of acetaldehyde derived N(2)-ethyl-2'-deoxyguanosine in human leukocyte DNA following alcohol consumption.
Epidemiological studies have shown an association between alcohol (ethanol) consumption and increased cancer risk. The effect of… Expand
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2009
2009
Evaluation of the DNA damaging potential of cannabis cigarette smoke by the determination of acetaldehyde derived N2-ethyl-2'-deoxyguanosine adducts.
Acetaldehyde is an ubiquitous genotoxic compound that has been classified as a possible carcinogen to humans. It can react with… Expand
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Highly Cited
2007
Highly Cited
2007
Application of the adductome approach to assess intertissue DNA damage variations in human lung and esophagus.
Methods for determining the differential susceptibility of human organs to DNA damage have not yet been explored to any large… Expand
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Highly Cited
2007
Highly Cited
2007
Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol.
N2-ethylidene-2'-deoxyguanosine (N2-ethylidene-dG) is a major DNA adduct induced by acetaldehyde. Although it is unstable in the… Expand
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Highly Cited
2006
Highly Cited
2006
Increased DNA damage in ALDH2-deficient alcoholics.
Drinking alcohol is a risk factor for cancers of the oral cavity, pharynx, larynx, and esophagus. Although many studies suggest… Expand
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Review
2005
Review
2005
DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis.
Alcoholic beverage consumption is classified as a known human carcinogen, causally related to an increased risk of cancer of the… Expand
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2004
2004
Enhancement of camptothecin-induced topoisomerase I cleavage complexes by the acetaldehyde adduct N2-ethyl-2'-deoxyguanosine.
The activity of DNA topoisomerase I (Top1), an enzyme that regulates DNA topology, is impacted by DNA structure alterations and… Expand
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2001
2001
Miscoding potential of the N2-ethyl-2'-deoxyguanosine DNA adduct by the exonuclease-free Klenow fragment of Escherichia coli DNA polymerase I.
Acetaldehyde, a major metabolite of ethanol, reacts with dG residues in DNA, resulting in the formation of the N(2)-ethyl-2… Expand
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Highly Cited
1999
Highly Cited
1999
Effective utilization of N2-ethyl-2'-deoxyguanosine triphosphate during DNA synthesis catalyzed by mammalian replicative DNA polymerases.
Acetaldehyde is produced by metabolic oxidation of ethanol after drinking alcoholic beverages. This agent reacts with nucleosides… Expand
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Highly Cited
1995
Highly Cited
1995
Development of a 32P-postlabelling method for the analysis of adducts arising through the reaction of acetaldehyde with 2'-deoxyguanosine-3'-monophosphate and DNA.
A 32P-postlabelling assay was developed for the analysis of adducts arising from the reaction of 2'-deoxyguanosine-3… Expand
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