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Epidemiological studies have identified chronic alcohol consumption as a significant risk factor for cancers of the upper… Expand Acetaldehyde is an ubiquitous genotoxic compound that has been classified as a possible carcinogen to humans. It can react with… Expand Methods for determining the differential susceptibility of human organs to DNA damage have not yet been explored to any large… Expand N2-ethylidene-2'-deoxyguanosine (N2-ethylidene-dG) is a major DNA adduct induced by acetaldehyde. Although it is unstable in the… Expand Drinking alcohol is a risk factor for cancers of the oral cavity, pharynx, larynx, and esophagus. Although many studies suggest… Expand Alcoholic beverage consumption is classified as a known human carcinogen, causally related to an increased risk of cancer of the… Expand The activity of DNA topoisomerase I (Top1), an enzyme that regulates DNA topology, is impacted by DNA structure alterations and… Expand Acetaldehyde, a major metabolite of ethanol, reacts with dG residues in DNA, resulting in the formation of the N(2)-ethyl-2… Expand Acetaldehyde is produced by metabolic oxidation of ethanol after drinking alcoholic beverages. This agent reacts with nucleosides… Expand A 32P-postlabelling assay was developed for the analysis of adducts arising from the reaction of 2'-deoxyguanosine-3… Expand