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N-hydroxyphenacetin glucuronide

Known as: beta-D-Glucopyranuronic acid, 1-((acetyl(4-ethoxyphenyl)amino)oxy)-1-deoxy-, phenacetin N-O-glucuronide 
 
National Institutes of Health

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Broader (1)

Phenacetin
analogs & derivatives

Papers overview

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1993
1993
Induction of renal pelvic carcinoma by phenacetin in hydronephrosis-bearing rats of the SD/cShi strain.
Carcinogenicity of phenacetin (PH) to the urinary tract was tested with the use of spontaneously hydronephrosis-bearing rats. In… Expand
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1987
1987
Metabolic activation of phenacetin and phenetidine by several forms of cytochrome P-450 purified from liver microsomes of rats and hamsters.
Metabolic activation of phenacetin by liver microsomes proceeds via both phenetidine and N-hydroxyphenacetin to direct-acting… Expand
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1985
1985
Formation of reactive metabolites of phenacetin in humans and rats.
The metabolism of phenacetin to reactive intermediates in humans was estimated from the excretion of thio adducts in urine. N… Expand
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1985
1985
The metabolism of N-hydroxyphenacetin in vitro and in vivo.
N-Hydroxyphenacetin (100 mg/kg) injected i.p. into rats rapidly appeared in the blood and disappeared with a t1/2 of 14 min… Expand
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1985
1985
Metabolism and nephrotoxicity of phenacetin and sulfanilamide.
The mechanisms of renal damage produced by sulfanilamide and phenacetin were studied. N-Hydroxyphenacetin, 4… Expand
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1984
1984
N-Hydroxy-N-arylacetamides
Abstract1.Of the two carcinogenic N-hydroxy-N-arylacetamides tested, N-hydroxy-4-acetylaminobiphenyl was as active as the… Expand
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1981
1981
Activation of N-hydroxyphenacetin to mutagenic and nucleic acid-binding metabolites by acyltransfer, deacylation, and sulfate conjugation.
N-Hydroxyphenacetin was activated to a mutagen in the Salmonella-Ames test by rabbit liver acyltransferase, rat liver cytosol… Expand
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