N-hydroxydebrisoquine

National Institutes of Health

Papers overview

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2008

2008

The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs.

Sanja Gruenewald, Bettina Wahl, +6 authors B. E. P. Clement
Journal of medicinal chemistry
2008

The recently discovered mammalian molybdoprotein mARC1 is capable of reducing N-hydroxylated compounds. Upon reconstitution with… (More)

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2005

2005

Metabolism of N-hydroxyguanidines (N-hydroxydebrisoquine) in human and porcine hepatocytes: reduction and formation of glucuronides.

Anja Kristina Froehlich, Ulrich Girreser, B. E. P. Clement
Drug metabolism and disposition: the biological…
2005

The biotransformation of N-hydroxydebrisoquine, a model substrate for N-hydroxyguanidines, was studied in vitro with cultured and… (More)

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1999

1999

Microsomal formation of nitric oxide and cyanamides from non-physiological N-hydroxyguanidines: N-hydroxydebrisoquine as a model substrate.

B. E. P. Clement, Jean Luc Boucher, Daniel Mansuy, A Harsdorf
Biochemical pharmacology
1999

The microsomal oxidative transformation of a non-physiological N-hydroxyguanidine was demonstrated for the first time for N… (More)

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1993

1993

Cytochrome P450 dependent N-hydroxylation of a guanidine (debrisoquine), microsomal catalysed reduction and further oxidation of the N-hydroxy-guanidine metabolite to the urea derivative. Similarity…

B. E. P. Clement, M H Schultze-Mosgau, H Wohlers
Biochemical pharmacology
1993

The microsomal N-hydroxylation of the strongly basic guanidinium group (debrisoquine) to N-hydroxyguanidine (N… (More)

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