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N-hydroxydebrisoquine

 
National Institutes of Health

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2 relations

Broader (1)

Debrisoquin
analogs & derivatives

Papers overview

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Highly Cited
2008
Highly Cited
2008
The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs.
The recently discovered mammalian molybdoprotein mARC1 is capable of reducing N-hydroxylated compounds. Upon reconstitution with… Expand
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2006
2006
Studium neuer Phase II-Reaktionen von ausgewählten Arzneistoffen mithilfe von Hepatozytenkulturen und UDP-Glucuronyltransferasen
Primare Hepatozytenkulturen stellen ein geeignetes in vitro-Modell fur Biotransformationsstudien und zur Aufklarung potenzieller… Expand
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2005
2005
METABOLISM OF N-HYDROXYGUANIDINES (N-HYDROXYDEBRISOQUINE) IN HUMAN AND PORCINE HEPATOCYTES: REDUCTION AND FORMATION OF GLUCURONIDES
The biotransformation of N-hydroxydebrisoquine, a model substrate for N-hydroxyguanidines, was studied in vitro with cultured and… Expand
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1999
1999
Microsomal formation of nitric oxide and cyanamides from non-physiological N-hydroxyguanidines: N-hydroxydebrisoquine as a model substrate.
The microsomal oxidative transformation of a non-physiological N-hydroxyguanidine was demonstrated for the first time for N… Expand
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1993
1993
Cytochrome P450 dependent N-hydroxylation of a guanidine (debrisoquine), microsomal catalysed reduction and further oxidation of the N-hydroxy-guanidine metabolite to the urea derivative. Similarity…
The microsomal N-hydroxylation of the strongly basic guanidinium group (debrisoquine) to N-hydroxyguanidine (N… Expand
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