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Of about one dozen human P450 s that catalyze biotransformations of xenobiotics, CYP2D6 is one of the more important ones based… Expand Cytochrome P450 2D6 (CYP2D6) metabolizes many important drugs. CYP2D6 activity ranges from complete deficiency to ultrafast… Expand One of the major causes of interindividual variation of drug effects is genetic variation of drug metabolism. Genetic… Expand Deficient hydroxylation of debrisoquine is an autosomal recessive trait that affects approximately 7% of the Caucasian population… Expand The frequency of poor metabolizers of debrisoquin was low and similar in four different native Chinese nationalities. In a total… Expand A method for genotyping poor metabolisers of debrisoquine is based on specific polymerase chain reaction (PCR) amplification of… Expand In population studies of individuals given the antihypertensive drug debrisoquine1,3, two distinct phenotypes have been described… Expand Interethnic differences in debrisoquin and mephenytoin hydroxylation have been compared between normal white (n = 183) and… Expand A population survey of 258 unrelated white British subjects showed a polymorphism for the 4-oxidation of debrisoquine. "Extensive… Expand Debrisoquine and its primary metabolite, 4-hydroxydebrisoquine, were measured in the urine of 94 volunteers after a single oral… Expand