Debrisoquin

Known as: 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-, Debrisoquine, Debrisochinum 
An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1964-2016
020406019642016

Papers overview

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Highly Cited
1999
Highly Cited
1999
Purpose. CYP3A and P-gp both function to reduce the intracellular concentration of drug substrates, one by metabolism and the… (More)
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Highly Cited
1997
Highly Cited
1997
Cytochrome P450 2D6 (CYP2D6) metabolizes many important drugs. CYP2D6 activity ranges from complete deficiency to ultrafast… (More)
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Highly Cited
1996
Highly Cited
1996
The debrisoquine hydroxylase (CYP2D6) catalyzes the oxidative metabolism of more than 40 different clinically important drugs… (More)
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Highly Cited
1993
Highly Cited
1993
Deficient hydroxylation of debrisoquine is an autosomal recessive trait that affects approximately 7% of the Caucasian population… (More)
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Highly Cited
1992
Highly Cited
1992
The frequency of poor metabolizers of debrisoquin was low and similar in four different native Chinese nationalities. In a total… (More)
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Highly Cited
1990
Highly Cited
1990
European data on the polymorphic metabolism of debrisoquine, sparteine, dextromethorphan and mephenytoin have been collected. No… (More)
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Highly Cited
1990
Highly Cited
1990
In previous papers we demonstrated that cyclosporin A (CsA) was specifically oxidized in rabbit and human liver by cytochrome P… (More)
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Highly Cited
1985
Highly Cited
1985
Dextromethorphan hydrobromide, 25 mg po, was given to 268 unrelated Swiss subjects to study urinary drug and metabolite profiles… (More)
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1983
1983
The hypothesis that variability in metoprolol metabolism stereoselectivity is related to debrisoquin oxidation phenotype was… (More)
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Highly Cited
1977
Highly Cited
1977
Debrisoquine and its primary metabolite, 4-hydroxydebrisoquine, were measured in the urine of 94 volunteers after a single oral… (More)
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