Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Debrisoquin

Known as: 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-, Debrisoquine, Debrisochinum 
An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2003
Review
2003
Of about one dozen human P450 s that catalyze biotransformations of xenobiotics, CYP2D6 is one of the more important ones based… Expand
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Highly Cited
1997
Highly Cited
1997
Cytochrome P450 2D6 (CYP2D6) metabolizes many important drugs. CYP2D6 activity ranges from complete deficiency to ultrafast… Expand
Review
1997
Review
1997
One of the major causes of interindividual variation of drug effects is genetic variation of drug metabolism. Genetic… Expand
  • table 1
  • table 2
  • table 3
  • figure 1
  • figure 2
Highly Cited
1993
Highly Cited
1993
Deficient hydroxylation of debrisoquine is an autosomal recessive trait that affects approximately 7% of the Caucasian population… Expand
Highly Cited
1992
Highly Cited
1992
  • Leif Bertilsson, Y. Lou, +7 authors Folke Sjöqvist
  • Clinical pharmacology and therapeutics
  • 1992
  • Corpus ID: 42831017
The frequency of poor metabolizers of debrisoquin was low and similar in four different native Chinese nationalities. In a total… Expand
Highly Cited
1990
Highly Cited
1990
A method for genotyping poor metabolisers of debrisoquine is based on specific polymerase chain reaction (PCR) amplification of… Expand
Highly Cited
1988
Highly Cited
1988
In population studies of individuals given the antihypertensive drug debrisoquine1,3, two distinct phenotypes have been described… Expand
Highly Cited
1985
Highly Cited
1985
Interethnic differences in debrisoquin and mephenytoin hydroxylation have been compared between normal white (n = 183) and… Expand
Review
1980
Review
1980
A population survey of 258 unrelated white British subjects showed a polymorphism for the 4-oxidation of debrisoquine. "Extensive… Expand
Highly Cited
1977
Highly Cited
1977
Debrisoquine and its primary metabolite, 4-hydroxydebrisoquine, were measured in the urine of 94 volunteers after a single oral… Expand