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Debrisoquin

Known as: 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-, Debrisoquine, Debrisochinum 
An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450… 
National Institutes of Health

Papers overview

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Review
2012
Review
2012
The concomitant use of herbal medicines and pharmacotherapy is wide spread. We have reviewed the literature to determine the… 
Review
2003
Review
2003
Of about one dozen human P450 s that catalyze biotransformations of xenobiotics, CYP2D6 is one of the more important ones based… 
Highly Cited
1997
Highly Cited
1997
Cytochrome P450 2D6 (CYP2D6) metabolizes many important drugs. CYP2D6 activity ranges from complete deficiency to ultrafast… 
Review
1997
Review
1997
One of the major causes of interindividual variation of drug effects is genetic variation of drug metabolism. Genetic… 
Highly Cited
1993
Highly Cited
1993
Deficient hydroxylation of debrisoquine is an autosomal recessive trait that affects approximately 7% of the Caucasian population… 
Highly Cited
1992
Highly Cited
1992
The frequency of poor metabolizers of debrisoquin was low and similar in four different native Chinese nationalities. In a total… 
Highly Cited
1988
Highly Cited
1988
In population studies of individuals given the antihypertensive drug debrisoquine1,3, two distinct phenotypes have been described… 
Highly Cited
1985
Highly Cited
1985
Interethnic differences in debrisoquin and mephenytoin hydroxylation have been compared between normal white (n = 183) and… 
Review
1980
Review
1980
A population survey of 258 unrelated white British subjects showed a polymorphism for the 4-oxidation of debrisoquine. "Extensive… 
Highly Cited
1977