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Debrisoquin

Known as: 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-, Debrisoquine, Debrisochinum 
An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450… 
National Institutes of Health

Related topics

Related topics

18 relations

Narrower (6)

3,4-dehydrodebrisoquine4-hydroxydebrisoquin8-hydroxydebrisoquinDebrisoquine sulfate

Broader (5)

Adrenergic AgentsAntihypertensive AgentsIsoquinolinesSympatholytics
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

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1986
1986
Debrisoquine oxidation in an Australian population.
The standard laboratory method for determination of debrisoquine phenotype has been modified and shortened with no loss of… 
Review
1986
Review
1986
Slow hydroxylation of tricyclic antidepressants--relationship to polymorphic drug oxidation.
There are marked interindividual differences in Css of tricyclic antidepressants. These are due mainly to corresponding… 
Review
1986
Review
1986
Polymorphic oxidation of debrisoquine and sparteine.
1983
1983
Antipyrine metabolism in relation to polymorphic oxidations of sparteine and debrisoquine.
Thirty-five healthy subjects who had been classified as extensive or poor metabolizers of both sparteine and debrisoquine were… 
1981
1981
Influence of the genetically controlled deficiency in debrisoquine hydroxylation on antipyrine metabolite formation.
The influence of the genetically controlled deficiency in debrisoquine hydroxylation on antipyrine metabolite formation was… 
1980
1980
Pathogenic and therapeutic significance of cardiovascular pressor reactivity as related to plasma catecholamines in borderline and established essential hypertension.
The role of the adrenergic effector-response axis in the pathogenesis of essential hypertension and in the hypotensive mechanism… 
1978
1978
The disposition of debrisoquine in hypertensive patients.
1 The urinary recovery and plasma concentration of debrisoquine (D) and its metabolite 4-hydroxydebrisoquine (HD) has been… 
1976
1976
Metabolism of debrisoquine sulphate in rat, dog and man.
1. The metabolism of debrisoquine sulphate in the dog has been studied and is similar to that in rat and man. 2. Two acidic… 
1975
1975
Metabolism of debrisoquine sulfate. Identification of some urinary metabolites in rat and man.
A high proportion of an oral dose of 14C-debrisoquine sulfate is excreted in the urine by rat and man. The urinary radioactivity… 
1966
1966
Studies on debrisoquine sulphate.
caused by bacterial strains whose patterns of resistance exclude the usual primary agents-sulphanilamide, nitrofurantoin, and…