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N-desmethyltamoxifen

Known as: cis-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine, demethyltamoxifen, Desmethyltamoxifen 
A main metabolite of the selective estrogen receptor modulator tamoxifen with anti-estrogen activity. N-desmethyltamoxifen blocks estrogen from… 
National Institutes of Health

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Tamoxifen
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Tamoxifen and its Main Metabolites Serum and Tissue Concentrations in Breast Cancer Women
Because of a possible relationship between tamoxifen (T) concentrations and clinical effects, we initiated a preliminary… 
2005
2005
FORMATION OF TAMOXIFEN-DNA ADDUCTS VIA O-SULFONATION, NOT O-ACETYLATION, OF α-HYDROXYTAMOXIFEN IN RAT AND HUMAN LIVERS
Tamoxifen (TAM) is used as the standard endocrine therapy for breast cancer patients and as a chemopreventive agent for women at… 
Highly Cited
2003
Highly Cited
2003
Quantification of tamoxifen and three metabolites in plasma by high-performance liquid chromatography with fluorescence detection: application to a clinical trial.
1997
1997
Determination of tamoxifen and metabolites in serum by capillary electrophoresis using a nonaqueous buffer system.
1997
1997
Solid-phase extraction and high-performance liquid chromatographic determination of tamoxifen and its major metabolites in breast tumour tissues.
1996
1996
Solid-phase extraction and high-performance liquid chromatographic determination of tamoxifen and its major metabolites in plasma.
1996
1996
On-line high-performance liquid chromatographic-electrospray ionization mass spectrometric method for the study of tamoxifen metabolism.
Highly Cited
1994
Highly Cited
1994
Direct determination of tamoxifen and its four major metabolites in plasma using coupled column high-performance liquid chromatography.
Highly Cited
1993
Highly Cited
1993
Inhibition of estrone sulfatase and 17β-hydroxysteroid dehydrogenase by antiestrogens
Highly Cited
1990
Highly Cited
1990
Decreased serum concentrations of tamoxifen and its metabolites induced by aminoglutethimide.
The antiestrogen tamoxifen and the aromatase inhibitor aminoglutethimide show similar response rates when used in the endocrine… 
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