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N-desmethyltamoxifen

Known as: cis-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine, demethyltamoxifen, Desmethyltamoxifen 
A main metabolite of the selective estrogen receptor modulator tamoxifen with anti-estrogen activity. N-desmethyltamoxifen blocks estrogen from… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
We explored whether breast cancer outcomes are associated with endoxifen and other metabolites of tamoxifen and examined… Expand
Highly Cited
2008
Highly Cited
2008
BACKGROUND Tamoxifen is hydroxylated by cytochrome P450 (CYP) 2D6 to the potent metabolites 4-hydroxytamoxifen (4OHtam) and 4… Expand
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Highly Cited
2006
Highly Cited
2006
N‐Desmethyltamoxifen (NDM), a major primary metabolite of tamoxifen, is hydroxylated by cytochrome P450 (CYP) 2D6 to yield… Expand
Highly Cited
2000
Highly Cited
2000
Patients treated with tamoxifen (TAM) for primary breast cancer often manifest de novo or acquired resistance, possibly through… Expand
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Highly Cited
1991
Highly Cited
1991
A procedure for the extraction of tamoxifen and metabolites from various rat and human tissues was developed and verified. With… Expand
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Highly Cited
1989
Highly Cited
1989
Several metabolites of tamoxifen, including 4-hydroxy-N-desmethyltamoxifen (metabolite BX), 4-hydroxytamoxifen (metabolite B), N… Expand
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Highly Cited
1986
Highly Cited
1986
The triphenylethylene antiestrogen tamoxifen has been shown previously to inhibit both calmodulin and protein kinase C activities… Expand
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Highly Cited
1983
Highly Cited
1983
The effects of two major metabolites of tamoxifen, N-demethyltamoxifen (DMT) and 4-hydroxytamoxifen (4OHT), on MCF-7 cell… Expand
Highly Cited
1982
Highly Cited
1982
The binding of [3H]tamoxifen ([3H]Tam), a nonsteroidal antiestrogen, and of 4-[3H]hydroxytamoxifen ([3H]OH-Tam), a metabolite… Expand
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Highly Cited
1981
Highly Cited
1981
The relative ability of the antiestrogen, tamoxifen, and its monohydroxy and desmethyl metabolites to displace tritiated… Expand