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N-desmethyltamoxifen

Known as: cis-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine, demethyltamoxifen, Desmethyltamoxifen 
A main metabolite of the selective estrogen receptor modulator tamoxifen with anti-estrogen activity. N-desmethyltamoxifen blocks estrogen from… 
National Institutes of Health

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N-demethyltamoxifen

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Tamoxifen
analogs & derivatives

Papers overview

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Highly Cited
2011
Highly Cited
2011
Tamoxifen Metabolite Concentrations, CYP2D6 Genotype, and Breast Cancer Outcomes
We explored whether breast cancer outcomes are associated with endoxifen and other metabolites of tamoxifen and examined… 
Highly Cited
2008
Highly Cited
2008
Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism.
BACKGROUND Tamoxifen is hydroxylated by cytochrome P450 (CYP) 2D6 to the potent metabolites 4-hydroxytamoxifen (4OHtam) and 4… 
Highly Cited
2006
Highly Cited
2006
Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: Implication for optimization of breast cancer treatment
Highly Cited
2003
Highly Cited
2003
Quantification of tamoxifen and three metabolites in plasma by high-performance liquid chromatography with fluorescence detection: application to a clinical trial.
Highly Cited
1991
Highly Cited
1991
Distribution of tamoxifen and its metabolites in rat and human tissues during steady-state treatment.
A procedure for the extraction of tamoxifen and metabolites from various rat and human tissues was developed and verified. With… 
Highly Cited
1990
Highly Cited
1990
Tamoxifen metabolites in patients on long-term adjuvant therapy for breast cancer.
Highly Cited
1989
Highly Cited
1989
Distribution of 4-hydroxy-N-desmethyltamoxifen and other tamoxifen metabolites in human biological fluids during tamoxifen treatment.
Several metabolites of tamoxifen, including 4-hydroxy-N-desmethyltamoxifen (metabolite BX), 4-hydroxytamoxifen (metabolite B), N… 
Highly Cited
1988
Highly Cited
1988
Estradiol-stimulated growth of MCF-7 tumors implanted in athymic mice: a model to study the tumoristatic action of tamoxifen.
Highly Cited
1988
Highly Cited
1988
Identification of 4-hydroxy-N-desmethyltamoxifen as a metabolite of tamoxifen in human bile.
The occurrence of tamoxifen metabolites in bile was investigated in a 57-year-old female patient receiving chronic treatment with… 
Highly Cited
1982
Highly Cited
1982
Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth.
The binding of [3H]tamoxifen ([3H]Tam), a nonsteroidal antiestrogen, and of 4-[3H]hydroxytamoxifen ([3H]OH-Tam), a metabolite… 
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