N-desmethyltamoxifen

Known as: cis-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine, demethyltamoxifen, Desmethyltamoxifen 
A main metabolite of the selective estrogen receptor modulator tamoxifen with anti-estrogen activity. N-desmethyltamoxifen blocks estrogen from… (More)
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

N-demethyltamoxifen

Broader (1)

Tamoxifen
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Tamoxifen metabolite concentrations, CYP2D6 genotype, and breast cancer outcomes.
We explored whether breast cancer outcomes are associated with endoxifen and other metabolites of tamoxifen and examined… (More)
  • figure 1
  • figure 2
  • table 1
  • table 2
  • table 4
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment.
BACKGROUND AND OBJECTIVES N-Desmethyltamoxifen (NDM), a major primary metabolite of tamoxifen, is hydroxylated by cytochrome P450… (More)
  • figure 2
  • figure 3
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Tamoxifen and metabolite concentrations in serum and breast cancer tissue during three dose regimens in a randomized preoperative trial.
PURPOSE Both therapeutic and adverse effects of tamoxifen may be related to its tissue concentrations. We investigated… (More)
  • figure 1
  • table 1
  • table 2
  • table 3
  • table 4
Is this relevant?
2004
2004
Interactions of tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen with P-glycoprotein and CYP3A.
The effects of tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen on transport attributable to P-glycoprotein were studied… (More)
Is this relevant?
Highly Cited
1991
Highly Cited
1991
Distribution of tamoxifen and its metabolites in rat and human tissues during steady-state treatment.
A procedure for the extraction of tamoxifen and metabolites from various rat and human tissues was developed and verified. With… (More)
  • figure 1
  • table 1
  • table 2
  • figure 2
  • table 3
Is this relevant?
Highly Cited
1991
Highly Cited
1991
Metabolites, pharmacodynamics, and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient.
The metabolism of tamoxifen was examined in the rat, mouse, and human breast cancer patient. Large oral doses of tamoxifen (200… (More)
Is this relevant?
Highly Cited
1989
Highly Cited
1989
Distribution of 4-hydroxy-N-desmethyltamoxifen and other tamoxifen metabolites in human biological fluids during tamoxifen treatment.
Several metabolites of tamoxifen, including 4-hydroxy-N-desmethyltamoxifen (metabolite BX), 4-hydroxytamoxifen (metabolite B), N… (More)
  • table 1
  • figure 2
  • figure 1
  • figure 3
  • figure 4
Is this relevant?
1988
1988
Identification of 4-hydroxy-N-desmethyltamoxifen as a metabolite of tamoxifen in human bile.
The occurrence of tamoxifen metabolites in bile was investigated in a 57-year-old female patient receiving chronic treatment with… (More)
  • table I
  • figure I
  • figure 2
  • figure 4
  • figure 3
Is this relevant?
1983
1983
Effects of biologically active metabolites of tamoxifen on the proliferation kinetics of MCF-7 human breast cancer cells in vitro.
The effects of two major metabolites of tamoxifen, N-demethyltamoxifen (DMT) and 4-hydroxytamoxifen (4OHT), on MCF-7 cell… (More)
Is this relevant?
1981
1981
Comparative binding affinities of tamoxifen, 4-hydroxytamoxifen, and desmethyltamoxifen for estrogen receptors isolated from human breast carcinoma: correlation with blood levels in patients with…
The relative ability of the antiestrogen, tamoxifen, and its monohydroxy and desmethyl metabolites to displace tritiated… (More)
Is this relevant?