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N-desmethyltamoxifen

Known as: cis-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine, demethyltamoxifen, Desmethyltamoxifen 
A main metabolite of the selective estrogen receptor modulator tamoxifen with anti-estrogen activity. N-desmethyltamoxifen blocks estrogen from… 
National Institutes of Health

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N-demethyltamoxifen

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Tamoxifen
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Tamoxifen and its Main Metabolites Serum and Tissue Concentrations in Breast Cancer Women
Because of a possible relationship between tamoxifen (T) concentrations and clinical effects, we initiated a preliminary… 
2005
2005
FORMATION OF TAMOXIFEN-DNA ADDUCTS VIA O-SULFONATION, NOT O-ACETYLATION, OF α-HYDROXYTAMOXIFEN IN RAT AND HUMAN LIVERS
Tamoxifen (TAM) is used as the standard endocrine therapy for breast cancer patients and as a chemopreventive agent for women at… 
2003
2003
Antioxidant inhibits tamoxifen-DNA adducts in endometrial explant culture.
1999
1999
Further characterization of the DNA adducts formed in rat liver after the administration of tamoxifen, N-desmethyltamoxifen or N, N-didesmethyltamoxifen.
The present study compares the formation of DNA adducts, determined by (32)P-postlabelling, in the livers of rats given tamoxifen… 
1997
1997
Determination of tamoxifen and metabolites in serum by capillary electrophoresis using a nonaqueous buffer system.
1996
1996
On-line high-performance liquid chromatographic-electrospray ionization mass spectrometric method for the study of tamoxifen metabolism.
Highly Cited
1994
Highly Cited
1994
Direct determination of tamoxifen and its four major metabolites in plasma using coupled column high-performance liquid chromatography.
1988
1988
Determination of tamoxifen and five metabolites in plasma.
1982
1982
High affinity binding of anti-oestrogen to the chick liver nuclear oestrogen receptor.
Tamoxifen is a potent inhibitor of specific oestrogen-induced yolk protein synthesis by chicken liver. The oestradiol receptor in… 
1981
1981
Induction of avian serum apolipoprotein II and vitellogenin by tamoxifen.
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