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N-desmethyltamoxifen

Known as: cis-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine, demethyltamoxifen, Desmethyltamoxifen 
A main metabolite of the selective estrogen receptor modulator tamoxifen with anti-estrogen activity. N-desmethyltamoxifen blocks estrogen from… Expand
National Institutes of Health

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3 relations

Narrower (1)

N-demethyltamoxifen

Broader (1)

Tamoxifen
analogs & derivatives

Papers overview

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Highly Cited
2008
Highly Cited
2008
Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism.
BACKGROUND Tamoxifen is hydroxylated by cytochrome P450 (CYP) 2D6 to the potent metabolites 4-hydroxytamoxifen (4OHtam) and 4… Expand
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Highly Cited
2006
Highly Cited
2006
Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: Implication for optimization of breast cancer treatment
N‐Desmethyltamoxifen (NDM), a major primary metabolite of tamoxifen, is hydroxylated by cytochrome P450 (CYP) 2D6 to yield… Expand
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Highly Cited
2000
Highly Cited
2000
Concentrations of tamoxifen and its major metabolites in hormone responsive and resistant breast tumours
Patients treated with tamoxifen (TAM) for primary breast cancer often manifest de novo or acquired resistance, possibly through… Expand
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Highly Cited
1991
Highly Cited
1991
Distribution of tamoxifen and its metabolites in rat and human tissues during steady-state treatment.
A procedure for the extraction of tamoxifen and metabolites from various rat and human tissues was developed and verified. With… Expand
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Highly Cited
1989
Highly Cited
1989
Distribution of 4-hydroxy-N-desmethyltamoxifen and other tamoxifen metabolites in human biological fluids during tamoxifen treatment.
Several metabolites of tamoxifen, including 4-hydroxy-N-desmethyltamoxifen (metabolite BX), 4-hydroxytamoxifen (metabolite B), N… Expand
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Highly Cited
1988
Highly Cited
1988
Identification of 4-hydroxy-N-desmethyltamoxifen as a metabolite of tamoxifen in human bile.
The occurrence of tamoxifen metabolites in bile was investigated in a 57-year-old female patient receiving chronic treatment with… Expand
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Highly Cited
1986
Highly Cited
1986
Calmodulin antagonism and growth-inhibiting activity of triphenylethylene antiestrogens in MCF-7 human breast cancer cells.
The triphenylethylene antiestrogen tamoxifen has been shown previously to inhibit both calmodulin and protein kinase C activities… Expand
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Highly Cited
1983
Highly Cited
1983
Effects of biologically active metabolites of tamoxifen on the proliferation kinetics of MCF-7 human breast cancer cells in vitro.
The effects of two major metabolites of tamoxifen, N-demethyltamoxifen (DMT) and 4-hydroxytamoxifen (4OHT), on MCF-7 cell… Expand
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Highly Cited
1982
Highly Cited
1982
Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth.
The binding of [3H]tamoxifen ([3H]Tam), a nonsteroidal antiestrogen, and of 4-[3H]hydroxytamoxifen ([3H]OH-Tam), a metabolite… Expand
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Highly Cited
1981
Highly Cited
1981
Comparative binding affinities of tamoxifen, 4-hydroxytamoxifen, and desmethyltamoxifen for estrogen receptors isolated from human breast carcinoma: correlation with blood levels in patients with…
The relative ability of the antiestrogen, tamoxifen, and its monohydroxy and desmethyl metabolites to displace tritiated… Expand
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