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N-desmethyltamoxifen
Known as:
cis-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine
, demethyltamoxifen
, Desmethyltamoxifen
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A main metabolite of the selective estrogen receptor modulator tamoxifen with anti-estrogen activity. N-desmethyltamoxifen blocks estrogen from…
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National Institutes of Health
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Related topics
Related topics
3 relations
Narrower (1)
N-demethyltamoxifen
Broader (1)
Tamoxifen
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Tamoxifen Metabolite Concentrations, CYP2D6 Genotype, and Breast Cancer Outcomes
L. Madlensky
,
L. Natarajan
,
+10 authors
J. Pierce
Clinical pharmacology and therapy
2011
Corpus ID: 7594544
We explored whether breast cancer outcomes are associated with endoxifen and other metabolites of tamoxifen and examined…
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Highly Cited
2008
Highly Cited
2008
Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism.
J. Gjerde
,
M. Hauglid
,
+6 authors
E. Lien
Annals of Oncology
2008
Corpus ID: 8787047
BACKGROUND Tamoxifen is hydroxylated by cytochrome P450 (CYP) 2D6 to the potent metabolites 4-hydroxytamoxifen (4OHtam) and 4…
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Highly Cited
2006
Highly Cited
2006
Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: Implication for optimization of breast cancer treatment
S. Borges
,
Z. Desta
,
+11 authors
D. Flockhart
Clinical pharmacology and therapy
2006
Corpus ID: 15096738
Highly Cited
2003
Highly Cited
2003
Quantification of tamoxifen and three metabolites in plasma by high-performance liquid chromatography with fluorescence detection: application to a clinical trial.
Kyung-Hoon Lee
,
B. Ward
,
Z. Desta
,
D. Flockhart
,
David R. Jones
Journal of chromatography. B, Analytical…
2003
Corpus ID: 41707132
Highly Cited
1991
Highly Cited
1991
Distribution of tamoxifen and its metabolites in rat and human tissues during steady-state treatment.
E. Lien
,
E. Solheim
,
P. Ueland
Cancer Research
1991
Corpus ID: 30459864
A procedure for the extraction of tamoxifen and metabolites from various rat and human tissues was developed and verified. With…
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Highly Cited
1990
Highly Cited
1990
Tamoxifen metabolites in patients on long-term adjuvant therapy for breast cancer.
S. Langan-Fahey
,
D. Tormey
,
V. Jordan
European Journal of Cancer
1990
Corpus ID: 36847422
Highly Cited
1989
Highly Cited
1989
Distribution of 4-hydroxy-N-desmethyltamoxifen and other tamoxifen metabolites in human biological fluids during tamoxifen treatment.
E. Lien
,
E. Solheim
,
O. Lea
,
S. Lundgren
,
S. Kvinnsland
,
P. Ueland
Cancer Research
1989
Corpus ID: 19646988
Several metabolites of tamoxifen, including 4-hydroxy-N-desmethyltamoxifen (metabolite BX), 4-hydroxytamoxifen (metabolite B), N…
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Highly Cited
1988
Highly Cited
1988
Estradiol-stimulated growth of MCF-7 tumors implanted in athymic mice: a model to study the tumoristatic action of tamoxifen.
M. Gottardis
,
S. Robinson
,
V. Jordan
Journal of Steroid Biochemistry
1988
Corpus ID: 11496676
Highly Cited
1988
Highly Cited
1988
Identification of 4-hydroxy-N-desmethyltamoxifen as a metabolite of tamoxifen in human bile.
E. Lien
,
E. Solheim
,
S. Kvinnsland
,
P. Ueland
Cancer Research
1988
Corpus ID: 3036130
The occurrence of tamoxifen metabolites in bile was investigated in a 57-year-old female patient receiving chronic treatment with…
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Highly Cited
1982
Highly Cited
1982
Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth.
E. Coezy
,
J. Borgna
,
H. Rochefort
Cancer Research
1982
Corpus ID: 14175365
The binding of [3H]tamoxifen ([3H]Tam), a nonsteroidal antiestrogen, and of 4-[3H]hydroxytamoxifen ([3H]OH-Tam), a metabolite…
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