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N-desmethyltamoxifen

Known as: cis-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine, demethyltamoxifen, Desmethyltamoxifen 
A main metabolite of the selective estrogen receptor modulator tamoxifen with anti-estrogen activity. N-desmethyltamoxifen blocks estrogen from… 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
We explored whether breast cancer outcomes are associated with endoxifen and other metabolites of tamoxifen and examined… 
Highly Cited
2008
Highly Cited
2008
BACKGROUND Tamoxifen is hydroxylated by cytochrome P450 (CYP) 2D6 to the potent metabolites 4-hydroxytamoxifen (4OHtam) and 4… 
Highly Cited
1991
Highly Cited
1991
A procedure for the extraction of tamoxifen and metabolites from various rat and human tissues was developed and verified. With… 
Highly Cited
1990
Highly Cited
1989
Highly Cited
1989
Several metabolites of tamoxifen, including 4-hydroxy-N-desmethyltamoxifen (metabolite BX), 4-hydroxytamoxifen (metabolite B), N… 
Highly Cited
1988
Highly Cited
1988
The occurrence of tamoxifen metabolites in bile was investigated in a 57-year-old female patient receiving chronic treatment with… 
Highly Cited
1982
Highly Cited
1982
The binding of [3H]tamoxifen ([3H]Tam), a nonsteroidal antiestrogen, and of 4-[3H]hydroxytamoxifen ([3H]OH-Tam), a metabolite…