N-desmethyltamoxifen

Known as: cis-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine, demethyltamoxifen, Desmethyltamoxifen 
A main metabolite of the selective estrogen receptor modulator tamoxifen with anti-estrogen activity. N-desmethyltamoxifen blocks estrogen from… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
We explored whether breast cancer outcomes are associated with endoxifen and other metabolites of tamoxifen and examined… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND AND OBJECTIVES N-Desmethyltamoxifen (NDM), a major primary metabolite of tamoxifen, is hydroxylated by cytochrome P450… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE Both therapeutic and adverse effects of tamoxifen may be related to its tissue concentrations. We investigated… (More)
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2004
2004
The effects of tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen on transport attributable to P-glycoprotein were studied… (More)
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Highly Cited
1991
Highly Cited
1991
A procedure for the extraction of tamoxifen and metabolites from various rat and human tissues was developed and verified. With… (More)
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Highly Cited
1991
Highly Cited
1991
The metabolism of tamoxifen was examined in the rat, mouse, and human breast cancer patient. Large oral doses of tamoxifen (200… (More)
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Highly Cited
1989
Highly Cited
1989
Several metabolites of tamoxifen, including 4-hydroxy-N-desmethyltamoxifen (metabolite BX), 4-hydroxytamoxifen (metabolite B), N… (More)
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1988
1988
The occurrence of tamoxifen metabolites in bile was investigated in a 57-year-old female patient receiving chronic treatment with… (More)
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1983
1983
The effects of two major metabolites of tamoxifen, N-demethyltamoxifen (DMT) and 4-hydroxytamoxifen (4OHT), on MCF-7 cell… (More)
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1981
1981
The relative ability of the antiestrogen, tamoxifen, and its monohydroxy and desmethyl metabolites to displace tritiated… (More)
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