N-demethyltramadol hydrochloride

OBJECTIVE To evaluate the analgesic potential of the centrally acting analgesics tramadol, morphine and the novel analgesic… Expand

The Thai medicinal plant Mitragyna speciosa (kratom) is misused as a herbal drug. Besides this, a new herbal blend has appeared… Expand

Dear Professor Dahlqvist, We read with interest the article by Fliegert et al. published online on May 20 that describes… Expand

Tramadol is an opioid drug metabolised in phase I by cytochrome P450 (CYP) enzymes, of which CYP2D6 is mainly responsible for the… Expand

In this study the role of cytochrome P450 2D (CYP2D) in the pharmacokinetic/pharmacodynamic relationship of (+)-tramadol [(+)-T… Expand

AIM To study the stereoselectivity in O-demethylation of trans tramadol. METHODS With or without quinine and quinidine as… Expand

A sensitive and stereoselective high-performance liquid chromatographic assay for the quantitative determination of the analgesic… Expand

A rapid, sensitive, precise and accurate capillary gas chromatographic assay with flame ionization detection was developed for… Expand

An achiral and chiral separation for the determination of tramadol and its main metabolite O‐demethyltramadol in urine samples by… Expand

In in vitro receptor binding and synaptosomal uptake experiments the (+)-enantiomer of tramadol (CAS 148229-78-1) is specific for… Expand