N-demethyltramadol hydrochloride

OBJECTIVE To evaluate the analgesic potential of the centrally acting analgesics tramadol, morphine and the novel analgesic… Expand

The Thai medicinal plant Mitragyna speciosa (kratom) is misused as a herbal drug. Besides this, a new herbal blend has appeared… Expand

The kinetics of tramadol enantiomers are stereoselective when doses of the racemic drug are given orally. To document whether the… Expand

Dear Professor Dahlqvist, We have read with interest the articles by Pedersen et al. and Wang et al. who highlighted the… Expand

Dear Professor Dahlqvist, We read with interest the article by Fliegert et al. published online on May 20 that describes… Expand

Tramadol is an opioid drug metabolised in phase I by cytochrome P450 (CYP) enzymes, of which CYP2D6 is mainly responsible for the… Expand

AIM To study the stereoselectivity in O-demethylation of trans tramadol. METHODS With or without quinine and quinidine as… Expand

A sensitive and stereoselective high-performance liquid chromatographic assay for the quantitative determination of the analgesic… Expand

In in vitro receptor binding and synaptosomal uptake experiments the (+)-enantiomer of tramadol (CAS 148229-78-1) is specific for… Expand

The respiratory and analgesic effects of i.v. meperidine, tramadol and their correlation with plasma concentrations of meperidine… Expand