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N-benzyladriamycin-14-valerate

National Institutes of Health

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AD 198

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Doxorubicin
analogs & derivatives

Papers overview

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2013
2013
N-Benzyladriamycin-14-valerate Accumulation Cells: P-Glycoprotein Expression without Reduced Resistance to N-Benzyladriamycin-14-valerate in Mouse J774.2
Ar-Benzyladriamycin-14-valerate (AD 198) Âis a highly lipophilic ana logue of Adriamycin with novel cytotoxic mechanisms, greater… 
2007
2007
N-Benzyladriamycin-14-valerate (AD 198) cytotoxicty circumvents Bcr-Abl anti-apoptotic signaling in human leukemia cells and also potentiates imatinib cytotoxicity.
2004
2004
Comparative uptake and retention of adriamycin andN-benzyladriamycin-14-valerate in human CEM leukemic lymphocyte cell cultures
SummaryN-Benzyladriamycin-14-valerate (AD 198) is a new lipophilic adriamycin (ADR) analogue that shows marked therapeutic… 
2002
2002
Novel extranuclear-targeted anthracyclines override the antiapoptotic functions of Bcl-2 and target protein kinase C pathways to induce apoptosis.
Bcl-2 inhibits apoptosis induced by numerous antitumor drugs, including doxorubicin and daunorubicin and is, thus, a major… 
1999
1999
Pharmacology of N-benzyladriamycin-14-valerate in the rat
Purpose: N-Benzyladriamycin-14-valerate (AD 198) is a semisynthetic anthracycline analogue superior to doxorubicin (DOX) both in… 
1993
1993
N-benzyladriamycin-14-valerate (AD 198)-resistant cells exhibit highly selective cross-resistance to other anthracyclines that circumvent multidrug resistance.
N-Benzyladriamycin-14-valerate (AD 198)-resistant murine J774.2 macrophage-like cells (A300) exhibited a novel mechanism of… 
1992
1992
Resistance to N-benzyladriamycin-14-valerate in mouse J774.2 cells: P-glycoprotein expression without reduced N-benzyladriamycin-14-valerate accumulation.
N-Benzyladriamycin-14-valerate (AD 198) is a highly lipophilic analogue of Adriamycin with novel cytotoxic mechanisms, greater in… 
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