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Norendoxifen, an active metabolite of tamoxifen, is a potent aromatase inhibitor. Little information is available regarding… Expand The tamoxifen-inducible Cre-loxP system is widely used to overcome gene targeting pre-adult lethality, to modify a specific cell… Expand The design and synthesis of dual aromatase inhibitors/selective estrogen receptor modulators (AI/SERMs) is an attractive strategy… Expand AIM
The aim was to examine the influence of CYP2C19 variants and associated haplotypes on the disposition of tamoxifen and its… Expand Tamoxifen is the standard-of-care treatment for estrogen receptor-positive premenopausal breast cancer. We examined tamoxifen… Expand Both selective estrogen receptor modulators and aromatase inhibitors are widely used for the treatment of breast cancer… Expand Tamoxifen, a selective estrogen receptor modulator, is important for the treatment and prevention of estrogen receptor (ER… Expand The first synthesis of the tamoxifen metabolite norendoxifen is reported. This included syntheses of (E)-norendoxifen, (Z… Expand Aromatase catalyzes the conversion of testosterone to estradiol and is the main source of endogenous estrogen in postmenopausal… Expand To improve the treatment of breast cancer, there has been a need for alternative aromatase inhibitors (AIs) that bring about… Expand