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N,N-didesmethyl-4-hydroxytamoxifen
Known as:
norendoxifen
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (1)
Tamoxifen
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
The Cytochrome P450 Enzyme Responsible for the Production of (Z)‐Norendoxifen in vitro
Jianli Ma
,
Zhong Chu
,
+4 authors
D. Tang
Chemistry & biodiversity
2018
Corpus ID: 3747302
Norendoxifen, an active metabolite of tamoxifen, is a potent aromatase inhibitor. Little information is available regarding…
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2016
2016
Tamoxifen in the Mouse Brain: Implications for Fate-Mapping Studies Using the Tamoxifen-Inducible Cre-loxP System
Martin Valny
,
P. Honsa
,
Denisa Kirdajova
,
Z. Kameník
,
M. Anderova
Front. Cell. Neurosci.
2016
Corpus ID: 9399069
The tamoxifen-inducible Cre-loxP system is widely used to overcome gene targeting pre-adult lethality, to modify a specific cell…
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2016
2016
Association of CYP2C19*2 and associated haplotypes with lower norendoxifen concentrations in tamoxifen-treated Asian breast cancer patients.
J. Lim
,
N. Sutiman
,
+10 authors
B. Chowbay
British journal of clinical pharmacology
2016
Corpus ID: 3755559
AIM The aim was to examine the influence of CYP2C19 variants and associated haplotypes on the disposition of tamoxifen and its…
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2016
2016
A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptors α and β.
Li‐Ming Zhao
,
Hai-Shan Jin
,
+5 authors
M. Cushman
Bioorganic & medicinal chemistry
2016
Corpus ID: 27159996
Highly Cited
2015
Highly Cited
2015
Tamoxifen metabolism predicts drug concentrations and outcome in premenopausal patients with early breast cancer
P. Saladores
,
T. Mürdter
,
+18 authors
H. Brauch
The Pharmacogenomics Journal
2015
Corpus ID: 288547
Tamoxifen is the standard-of-care treatment for estrogen receptor-positive premenopausal breast cancer. We examined tamoxifen…
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2015
2015
Design and synthesis of norendoxifen analogues with dual aromatase inhibitory and estrogen receptor modulatory activities.
Wei-Ke Lv
,
Jinzhong Liu
,
T. Skaar
,
D. Flockhart
,
M. Cushman
Journal of medicinal chemistry
2015
Corpus ID: 25363823
Both selective estrogen receptor modulators and aromatase inhibitors are widely used for the treatment of breast cancer…
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Review
2013
Review
2013
PharmGKB summary: tamoxifen pathway, pharmacokinetics
D. Klein
,
C. Thorn
,
Z. Desta
,
D. Flockhart
,
R. Altman
,
T. Klein
Pharmacogenetics and genomics
2013
Corpus ID: 20176202
Tamoxifen, a selective estrogen receptor modulator, is important for the treatment and prevention of estrogen receptor (ER…
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2013
2013
Synthesis of mixed (E,Z)-, (E)-, and (Z)-norendoxifen with dual aromatase inhibitory and estrogen receptor modulatory activities.
Wei-Ke Lv
,
Jinzhong Liu
,
Deshun Lu
,
D. Flockhart
,
M. Cushman
Journal of medicinal chemistry
2013
Corpus ID: 36637290
The first synthesis of the tamoxifen metabolite norendoxifen is reported. This included syntheses of (E)-norendoxifen, (Z…
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2013
2013
Inhibition of Cytochrome P450 Enzymes by the E- and Z-Isomers of Norendoxifen
Jinzhong Liu
,
Peter J Flockhart
,
+5 authors
D. Flockhart
Drug Metabolism and Disposition
2013
Corpus ID: 1853032
Aromatase catalyzes the conversion of testosterone to estradiol and is the main source of endogenous estrogen in postmenopausal…
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Highly Cited
2011
Highly Cited
2011
The tamoxifen metabolite norendoxifen is a potent and selective inhibitor of aromatase (CYP19) and a potential lead compound for novel therapeutic agents
Wenjie Lu
,
Cong Xu
,
Zifan Pei
,
Abdelrahman S. Mayhoub
,
M. Cushman
,
D. Flockhart
Breast Cancer Research and Treatment
2011
Corpus ID: 22096941
To improve the treatment of breast cancer, there has been a need for alternative aromatase inhibitors (AIs) that bring about…
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