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Myosin-9

Known as: Cellular Myosin Heavy Chain, Type A, Myosin Heavy Chain, Non-Muscle IIa, Non-Muscle Myosin Heavy Polypeptide 9 
Myosin-9 (1960 aa, ~227 kDa) is encoded by the human MYH9 gene. This protein is involved in both cell shape and cytokinesis.
National Institutes of Health

Related topics

Related topics

13 relations
Angiogenic ProcessCell MovementCytokinesisCytoskeletal Gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expression.
FPD/AML is a familial platelet disorder characterized by platelet defects, predisposition to acute myelogenous leukemia (AML) and… 
Highly Cited
2012
Highly Cited
2012
SnapShot: Mammalian Rab Proteins in Endocytic Trafficking
Highly Cited
2011
Highly Cited
2011
The role of non-muscle myosin IIA in aggregation and invasion of human MCF-7 breast cancer cells.
Human MCF-7/6 breast cancer cells differ from their MCF-7/AZ counterparts by their invasiveness in a number of assays in vitro… 
Review
2010
Review
2010
Advances in the understanding of MYH9 disorders
Purpose of reviewMYH9 disorders are autosomal dominant macrothrombocytopenias with leukocyte inclusion bodies caused by mutations… 
Highly Cited
2010
Highly Cited
2010
Heavy chain myosin 9-related disease (MYH9-RD): Neutrophil inclusions of myosin-9 as a pathognomonic sign of the disorder
Summary MYH9-related disease (MYH9-RD) is an autosomal dominant thrombocytopenia with giant platelets variably associated with… 
Highly Cited
2009
Highly Cited
2009
Myocardin-Related Transcription Factors and SRF are required for cytoskeletal dynamics, invasion and experimental metastasis
Rho GTPases control cytoskeletal dynamics through cytoplasmic effectors and regulate transcriptional activation through myocardin… 
Highly Cited
2009
Highly Cited
2009
Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation.
Mutations in the MYH9 gene encoding nonmuscle myosin IIA lead to macrothrombocytopenia as observed in MYH9-related disorders. We… 
Highly Cited
2007
Highly Cited
2007
The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway.
The gene implicated in the May-Hegglin anomaly and related macrothrombocytopenias, MYH9, encodes myosin-IIA, a protein that… 
Highly Cited
2004
Highly Cited
2004
Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO…
Highly Cited
2000
Highly Cited
2000
Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9.
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