FAQ

MutSalpha complex

Known as: MSH2/MSH6 complex, MSH2/MSH6 complex location, MutSalpha complex location 
A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2016
01220002016

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
A MutSβ-Dependent Contribution of MutSα to Repeat Expansions in Fragile X Premutation Mice?
The fragile X-related disorders result from expansion of a CGG/CCG microsatellite in the 5' UTR of the FMR1 gene. We have… (More)
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2016
2016
UHRF1 is a sensor for DNA interstrand crosslinks
The human genome is guarded against mutations by several DNA repair pathways. Common for all pathways, is the initiating event of… (More)
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2006
2006
Analysis of the human MutLalpha.MutSalpha complex.
Human DNA mismatch repair is initiated by MutSalpha which ATP-dependently recruits MutLalpha. Analysis of this complex is… (More)
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2005
2005
PCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cells.
Modified bases, such as O6-methylguanines, are produced in cells exposed to alkylating agents and cause apoptosis. In human cells… (More)
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2002
2002
Phosphorylation of mismatch repair proteins MSH2 and MSH6 affecting MutSalpha mismatch-binding activity.
Mismatch repair (MMR) is involved in the removal of mispaired bases from DNA and thus plays an important role in the maintenance… (More)
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2001
2001
A novel protein complex distinct from mismatch repair binds thioguanylated DNA.
To elucidate molecular mechanism(s) of cellular response to mercaptopurine, a widely used antileukemic agent, we assessed… (More)
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2000
2000
Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents.
Mammalian mismatch repair has been implicated in mismatch correction, the prevention of mutagenesis and cancer, and the induction… (More)
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