• Publications
  • Influence
Serum miR-122 as a Biomarker of Necroinflammation in Patients With Chronic Hepatitis C Virus Infection
OBJECTIVES:The liver contains large amounts of microRNA-122 (miR-122), whereas other tissues contain only marginal amounts of this miRNA. MicroRNAs have also been found to circulate in the blood in aExpand
  • 170
  • 11
Dysregulation of global microRNA expression in splenic marginal zone lymphoma and influence of chronic hepatitis C virus infection
The precise molecular pathogenesis of splenic marginal zone lymphoma (SMZL) is still unknown. Clinical and epidemiological data suggest that chronic hepatitis C virus (HCV) infection may have anExpand
  • 84
  • 9
Proton pump inhibitor treatment is associated with the severity of liver disease and increased mortality in patients with cirrhosis
Proton pump inhibitors (PPI) are widely used in patients with liver diseases. Within the last years, there have been concerns about the PPI use as they may promote infections in patients withExpand
  • 67
  • 7
  • PDF
Epac activation converts cAMP from a proliferative into a differentiation signal in PC12 cells.
Elevation of the intracellular cAMP concentration ([cAMP]i) regulates metabolism, cell proliferation, and differentiation and plays roles in memory formation and neoplastic growth. cAMP mediates itsExpand
  • 118
  • 6
  • PDF
Regulation of Protein Kinase C-related Protein Kinase 2 (PRK2) by an Intermolecular PRK2-PRK2 Interaction Mediated by Its N-terminal Domain*
Background: Protein kinase C-related kinases (PRKs) are involved in the development of cancer and hepatitis C. Results: N-terminal domains of PRK2 inhibit the interaction with its upstream kinase andExpand
  • 22
  • 6
Serum microRNA‐122 levels in different groups of patients with chronic hepatitis B virus infection
Summary.  miR‐122 is a liver‐specific microRNA, which also circulates in the blood. The levels of miR‐122 in serum and plasma correlate with hepatic necroinflammation in patients with hepatitis BExpand
  • 100
  • 5
Cyclic AMP Induces Transactivation of the Receptors for Epidermal Growth Factor and Nerve Growth Factor, Thereby Modulating Activation of MAP Kinase, Akt, and Neurite Outgrowth in PC12 Cells*
In PC12 cells, a well studied model for neuronal differentiation, an elevation in the intracellular cAMP level increases cell survival, stimulates neurite outgrowth, and causes activation ofExpand
  • 91
  • 5
Serum microRNA-1 and microRNA-122 are prognostic markers in patients with hepatocellular carcinoma.
BACKGROUND The identification of new biomarkers to predict the aggressiveness of hepatocellular carcinoma (HCC) and supplement the current set of prognosis and treatment algorithms is an importantExpand
  • 137
  • 5
Inhibition of RNAse A family enzymes prevents degradation and loss of silencing activity of siRNAs in serum.
Small interfering RNAs (siRNA), RNA duplexes of approximately 21 nucleotides, offer a promising approach to specifically degrade RNAs in target cells by a process termed RNA interference.Expand
  • 109
  • 5
Mutations in the MutSα interaction interface of MLH1 can abolish DNA mismatch repair
MutLα, a heterodimer of MLH1 and PMS2, plays a central role in human DNA mismatch repair. It interacts ATP-dependently with the mismatch detector MutSα and assembles and controls further repairExpand
  • 60
  • 5
  • PDF