Multidrug Resistance Modulator

Known as: Multidrug-Resistance Antagonists, Multidrug-Resistance Chemo Sensitizers, Chemosensitizer 
A drug that makes tumor cells more sensitive to the effects of chemotherapy.
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy. Through the development of a drug… (More)
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Highly Cited
2007
Highly Cited
2007
Abundant evidence suggests that a unifying principle governing the molecular pathology of cancer is the co-dependent aberrant… (More)
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Review
2004
Review
2004
The multidrug resistance-1 (MDR1) gene product, P-glycoprotein (P-gp), and the multidrug resistance-related proteins (MRPs) are… (More)
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Highly Cited
2002
Highly Cited
2002
The Cancer and Leukemia Group B conducted a phase 3 trial of the P-glycoprotein modulator PSC-833 in untreated acute myeloid… (More)
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Highly Cited
2001
Highly Cited
2001
It has been shown that serum levels of interleukin (IL)-6 are elevated in patients with various types of cancer. However, the… (More)
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Highly Cited
2000
Highly Cited
2000
Fumitremorgin C (FTC) is a potent and specific chemosensitizing agent in cell lines selected for resistance to mitoxantrone that… (More)
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Highly Cited
1999
Highly Cited
1999
The P-glycoprotein multidrug transporter functions as an ATP-driven efflux pump for a large number of structurally unrelated… (More)
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Highly Cited
1998
Highly Cited
1998
We selected a human colon carcinoma cell line in increasing concentrations of mitoxantrone to obtain a resistant subline, S1-M1-3… (More)
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Review
1997
Review
1997
 Multidrug resistance (MDR) describes the phenomenon of simultaneous resistance to unrelated drugs. It has been a decade since… (More)
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Highly Cited
1991
Highly Cited
1991
The new nonimmunosuppressive cyclosporin analogue, SDZ PSC 833, is a very potent multidrug-resistance modifier. In vitro, it was… (More)
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