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Multidrug Resistance Modulator

Known as: Multidrug-Resistance Antagonists, Multidrug-Resistance Chemo Sensitizers, Chemosensitizer 
A drug that makes tumor cells more sensitive to the effects of chemotherapy.
National Institutes of Health

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Pharmaceutical Preparations

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
SRC tyrosine kinase and multidrug resistance protein-1 inhibitions act independently but cooperatively to restore paclitaxel sensitivity to paclitaxel-resistant ovarian cancer cells.
Src tyrosine kinase has been found to be overexpressed in both mouse and human ovarian cancer cells as well as in human primary… 
Highly Cited
2004
Highly Cited
2004
Complete reversal of multidrug resistance by stable expression of small interfering RNAs targeting MDR1
Overexpression of P-glycoprotein, encoded by the MDR1 gene, confers multidrug resistance (MDR) on cancer cells and is a frequent… 
2004
2004
Caveolin-1 gene is coordinately regulated with the multidrug resistance 1 gene in normal and leukemic bone marrow.
Review
2004
Review
2004
Pharmacologic circumvention of multidrug resistance
The ability of malignant cells to develop resistance to chemotherapeutic drugs is a major obstacle to the successful treatment of… 
Highly Cited
2001
Highly Cited
2001
Expression of MRP1 and related transporters in human lung cells in culture.
Highly Cited
2000
Highly Cited
2000
Multidrug resistance-1 (MDR-1) in rheumatic autoimmune disorders. Part II: Increased P-glycoprotein activity in lymphocytes from systemic lupus erythematosus patients might affect steroid…
BACKGROUND Over-expression of the membrane glycoprotein called P-glycoprotein has been widely observed in a variety of both… 
Highly Cited
1996
Highly Cited
1996
High-dose multidrug resistance in primary human hematopoietic progenitor cells transduced with optimized retroviral vectors.
Retroviral transfer of the multidrug-resistance 1 (mdr1) cDNA into primary human hematopoietic progenitor cells (HPC) of cancer… 
Highly Cited
1996
Highly Cited
1996
Modulation of the function of human MDR1 P-glycoprotein by the antimalarial drug mefloquine.
Highly Cited
1995
Highly Cited
1995
Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy.
PURPOSE Dexverapamil is a competitive inhibitor of the P-glycoprotein (Pgp) efflux pump, a potent mechanism of multidrug… 
Review
1990
Review
1990
Genetic basis of multidrug resistance of tumor cells
Multidrug resistance in animal cells is defined as the simultaneous resistance to a variety of compounds which appear to be… 
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