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Mucosal-Associated Invariant T-Cell

Known as: Cell, MAIT, MAIT Cell, Cells, MAIT 
A T-cell subtype bearing a semi-invariant T-cell receptor and restricted by the major histocompatibility complex related molecule MR1. These cells… 
National Institutes of Health

Related topics

Related topics

6 relations
Hematopoietic and Lymphoid TissueLymphoid TissueMicrobiologicalProcess of secretion

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Mucosal-Associated Invariant T Cells in Inflammatory Bowel Diseases: Bystanders, Defenders, or Offenders?
The quest for new therapeutics and better follow-up of patients with inflammatory bowel diseases (IBD) requires the clearest… 
2011
2011
α-Galactosylceramide–Induced Airway Eosinophilia Is Mediated through the Activation of NKT Cells
Invariant NKT (iNKT) cells bridge innate and adaptive immune responses, resulting in the expansion of Ag-specific B and T cell… 
Highly Cited
2010
Highly Cited
2010
iNKT Cells Control Mouse Spontaneous Carcinoma Independently of Tumor-Specific Cytotoxic T Cells
Background CD1d-restricted invariant NKT (iNKT) cells are a subset of T lymphocytes endowed with innate effector functions that… 
Review
2010
Review
2010
Bacteria, mucosal‐associated invariant T cells and MR1
Certain subpopulations of T lymphoctyes show innate-like properties that distinguish them from conventional T cells and thus have… 
Highly Cited
2009
Highly Cited
2009
Selective Requirement for c-Myc at an Early Stage of Vα14i NKT Cell Development 1
Vα14 invariant (Vα14i) NKT cells are a subset of regulatory T cells that utilize a semi-invariant TCR to recognize glycolipids… 
2009
2009
Invariant TCR Rather Than CD1d Shapes the Preferential Activities of C-Glycoside Analogues Against Human Versus Murine Invariant NKT Cells1
C-glycoside analogues of α-galactosylceramide were shown to activate both human and mouse invariant NKT (iNKT) cells. Among these… 
Highly Cited
2007
Highly Cited
2007
Invariant NKT Cells Biased for IL-5 Production Act as Crucial Regulators of Inflammation1
Although invariant NKT (iNKT) cells play a regulatory role in the pathogenesis of autoimmune diseases and allergy, an initial… 
2007
2007
The Pro-Th1 Cytokine IL-12 Enhances IL-4 Production by Invariant NKT Cells: Relevance for T Cell-Mediated Hepatitis1
IL-12 is essential for invariant NKT (iNKT) cells because it can maintain a functionally active population and promote a cytokine… 
2007
2007
Subcongenic analysis of genetic basis for impaired development of invariant NKT cells in NOD mice
Reduced numbers and function of invariant NKT (iNKT) cells partially contribute to type 1 diabetes (T1D) development in NOD mice… 
Highly Cited
2003
Highly Cited
2003
Structural Features of the Acyl Chain Determine Self-phospholipid Antigen Recognition by a CD1d-restricted Invariant NKT (iNKT) Cell*
Little is known about the antigen specificity of CD1d-restricted T cells, except that they frequently recognize CD1d-expressing… 
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