Mucosal-Associated Invariant T-Cell

Known as: Cell, MAIT, MAIT Cell, Cells, MAIT 
A T-cell subtype bearing a semi-invariant T-cell receptor and restricted by the major histocompatibility complex related molecule MR1. These cells… (More)
National Institutes of Health

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Hematopoietic and Lymphoid TissueLymphoid TissueMicrobiologicalProcess of secretion
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Highly Cited
2015
Highly Cited
2015
Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients.
Obesity and type 2 diabetes (T2D) are associated with low-grade inflammation, activation of immune cells, and alterations of the… (More)
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2014
2014
Mucosal-associated invariant T cell deficiency in systemic lupus erythematosus.
Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections and play an… (More)
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Highly Cited
2013
Highly Cited
2013
Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells
Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor (TCR) α-chain, TRAV1-2-TRAJ33, and are… (More)
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Highly Cited
2013
Highly Cited
2013
Recognition of vitamin B metabolites by mucosal-associated invariant T cells.
The mucosal-associated invariant T-cell antigen receptor (MAIT TCR) recognizes MR1 presenting vitamin B metabolites. Here we… (More)
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Highly Cited
2013
Highly Cited
2013
IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells.
Human mucosal-associated invariant T (MAIT) cells are a T cell population characterized by the expression of a semi-invariant TCR… (More)
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2012
2012
Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor
Mucosal-associated invariant T (MAIT) cells express a semiinvariant αβ T cell receptor (TCR) that binds MHC class I-like molecule… (More)
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Highly Cited
2011
Highly Cited
2011
Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis.
Mucosal-associated invariant T (MAIT) cells are innate T cells expressing an invariant Vα7.2-Jα33 T-cell antigen receptor α chain… (More)
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Highly Cited
2010
Highly Cited
2010
Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells
Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of which CD8+ T cells play a unique role… (More)
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Highly Cited
2010
Highly Cited
2010
Antimicrobial activity of mucosal-associated invariant T cells
Mucosal-associated invariant T lymphocytes (MAIT lymphocytes) are characterized by two evolutionarily conserved features: an… (More)
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Highly Cited
2003
Highly Cited
2003
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
The evolutionary conservation of T lymphocyte subsets bearing T-cell receptors (TCRs) using invariant α-chains is indicative of… (More)
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