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Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes
It is shown that α-GalCer treatment, even when initiated after the onset of insulitis, protects female N OD mice from T1D and prolongs the survival of pancreatic islets transplanted into newly diabetic NOD mice, raising the possibility thatα-galactosylceramide treatment might be used therapeutically to prevent the onset and recurrence of human T1d.
The pro‐Th2 cytokine IL‐33 directly interacts with invariant NKT and NK cells to induce IFN‐γ production
Data support the conclusion that IL‐33 can contribute as a co‐stimulatory factor to innate cellular immune responses as well as in combination with the pro‐inflammatory cytokine IL‐12.
Early quantitative and functional deficiency of NK1+‐like thymocytes in the NOD mouse
- J. Gombert, A. Herbelin, E. Tancrède‐Bohin, M. Dy, C. Carnaud, J. Bach
- Biology, MedicineEuropean journal of immunology
- 1 December 1996
A very early defect in NK1+‐like T cells is demonstrated which could be involved in the genesis of autoimmunity in NOD mice through a deficiency in Th2 cell function.
Evidence for eomesodermin‐expressing innate‐like CD8+ KIR/NKG2A+ T cells in human adults and cord blood samples
Evidence is provided for a population of KIR/NKG2A+CD8+ T cells in healthy human adults sharing the same features, namely increased Eomes expression, prompt IFN‐γ production in response to innate‐like stimulation by IL‐12+IL‐18, and a potent antigen‐independent cytotoxic activity along with a preferential terminally differentiated effector memory phenotype.
Elevated circulating levels of interleukin-6 in patients with chronic renal failure.
- A. Herbelin, P. Ureña, A. Nguyen, J. Zingraff, B. Descamps-Latscha
- Biology, MedicineKidney international
- 1 May 1991
Plasma IL-6 activity was significantly increased in patients with chronic renal failure and that of tumor necrosis factor alpha in both long-term and not yet dialyzed uremic patients, and a close correlation existed between the biological activity ofIL-6 and its immunoreactive level.
Cutting Edge: Invariant Vα14 NKT Cells Are Required for Allergen-Induced Airway Inflammation and Hyperreactivity in an Experimental Asthma Model1
- M. Lisbonne, Séverine Diem, M. Leite-de-Moraes
- Biology, MedicineThe Journal of Immunology
- 15 August 2003
Findings clearly demonstrate that iVα14 NKT cells are required to participate in allergen-induced Th2 airway inflammation through a CD1d-dependent mechanism.
A distinct IL-18-induced pathway to fully activate NK T lymphocytes independently from TCR engagement.
Evidence for activation of NK T lymphocytes in response to IL-18 plus IL-12 in the absence of TCR engagement together with the maintenance of preferential IFN-gamma vs IL-4 production upon subsequent exposure to specific Ags is consistent with the active participation of this cell population in innate as well as acquired cellular immune responses.
Invariant NKT cells inhibit development of the Th17 lineage
It is suggested that iNKT cells provide a natural barrier against Th17 responses, and a role for IL-4, IL-10, and IFN-γ in the iN KT-cell-mediated regulation of T-cell lineage development is revealed.
Establishing the relationship between complement activation and stimulation of phagocyte oxidative metabolism in hemodialyzed patients: a randomized prospective study.
This study confirms that, coincident with the nadir of leukopenia observed at T15, dialysis with CUP but not PAN membranes induces a marked rise in C3a antigen levels and profound alterations in whole blood CL production consisting of a dramatic increase in basal CL and a significant loss in CL response capacity to stimulating agents.