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Moxalactam

Known as: 5-Oxa-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((carboxy(4-hydroxyphenyl)acetyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, Latamoxef, moxam 
A semisynthetic oxa-beta-lactam antibiotic, with antibacterial activity used mainly against gram-negative aerobic bacteria. Replacing the beta-lactam… 
National Institutes of Health

Related topics

Related topics

18 relations

Narrower (6)

1-Oxacephalosporin6059-SDisodium LatamoxefLilly 127935

Broader (2)

Anti-Bacterial AgentsMonobactams
In BloodMoxalactam:MCnc:Pt:Ser/Plas:QnMoxalactam:Susc:Pt:Isolate:OrdQnMoxalactam:Susc:Pt:Isolate:OrdQn:MIC

Papers overview

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Highly Cited
1999
Highly Cited
1999
Prediction of Clearance, Volume of Distribution and Half‐life by Allometric Scaling and by use of Plasma Concentrations Predicted from Pharmacokinetic Constants: a Comparative Study
  • I. Mahmood
  • The Journal of pharmacy and pharmacology
  • 1999
  • Corpus ID: 20717873
Pharmacokinetic parameters (clearance, CL, volume of distribution in the central compartment, VdC, and elimination half‐life, t… 
Highly Cited
1986
Highly Cited
1986
The in-vivo postantibiotic effect of imipenem and other new antimicrobials.
The postantibiotic effect (PAE) in vivo of imipenem, cefoperazone and latamoxef was investigated in a neutropenic mouse thigh… 
Highly Cited
1986
Highly Cited
1986
Improved Listeria monocytogenes selective agar
By increasing the LiCl concentration to 5 g/liter and adding 20 mg of moxalactam per liter to modified McBride agar base, it was… 
Highly Cited
1985
Highly Cited
1985
Drug induced red blood cell autoantibodies co‐developed with drug specific antibodies causing haemolytic anaemias
Summary. Four individuals with anti‐glafenine, anti‐latamoxef and anti‐teniposide antibodies were found to have an associated red… 
Highly Cited
1984
Highly Cited
1984
Moxalactam plus ticarcillin or tobramycin for treatment of febrile episodes in neutropenic cancer patients.
Moxalactam disodium in combination with ticarcillin disodium or tobramycin sulfate was used to treat 445 episodes of suspected or… 
Highly Cited
1982
Highly Cited
1982
Effects of moxalactam on blood coagulation and platelet function.
Bleeding complications have occasionally been reported in clinical trials of moxalactam therapy for debilitated and/or… 
Highly Cited
1982
Highly Cited
1982
Coagulopathy associated with the use of moxalactam.
MOXALACTAM disodium (Moxam) is a new β-lactam antibiotic with a broad clinical spectrum and is considered by some a third… 
Highly Cited
1982
Highly Cited
1982
Emergence of resistance to beta-lactam and aminoglycoside antibiotics during moxalactam therapy of Pseudomonas aeruginosa infections
In four patients with Pseudomonas aeruginosa infections, the infecting strain developed resistance to moxalactam during therapy… 
Highly Cited
1981
Highly Cited
1981
Moxalactam therapy for bacterial infections.
Moxalactam, a novel beta-lactam antimicrobial agent in which oxygen has replaced sulfur in the six-membered ring of the… 
Highly Cited
1980
Highly Cited
1980
Moxalactam (6059-S), a Novel 1-Oxa-β-Lactam with an Expanded Antibacterial Spectrum: Laboratory Evaluation
Moxalactam (6059-S) {7β-[2-carboxy-2-(4-hydroxyphenyl)acetamido]-7α-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]-methyl]-1-oxa-1… 
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