Monophthalmos

Known as: Monophthalmia, Synophthalmia, Cyclopia 
A rare congenital abnormality characterized by the failure of the embryonic prosencephalon to separate the eye orbit into two distinct cavities… (More)
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
BACKGROUND AND AIMS Species of the genus Burkholderia, from the Betaproteobacteria, have been isolated from legume nodules, but… (More)
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Highly Cited
2000
Highly Cited
2000
Holoprosencephaly (HPE) is the most common structural defect of the developing forebrain in humans (1 in 250 conceptuses, 1 in 16… (More)
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Highly Cited
2000
Highly Cited
2000
In vertebrates, specification of anteroposterior (A/P) and left-right (L/R) axes depends on TGFbeta-related signals, including… (More)
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Highly Cited
1999
Highly Cited
1999
There is growing evidence that implicates a role for Sonic hedgehog (SHH) in morphogenesis of the craniofacial complex. Mutations… (More)
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Highly Cited
1999
Highly Cited
1999
The type II activin receptors, ActRIIA and ActRIIB, have been shown to play critical roles in axial patterning and organ… (More)
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Highly Cited
1998
Highly Cited
1998
Veratrum alkaloids and distal inhibitors of cholesterol biosynthesis have been studied for more than 30 years as potent… (More)
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Highly Cited
1998
Highly Cited
1998
The steroidal alkaloid cyclopamine produces cyclopia and holoprosencephaly when administered to gastrulation-stage amniote… (More)
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Highly Cited
1998
Highly Cited
1998
Zebrafish cyclops (cyc) mutations cause deficiencies in the dorsal mesendoderm, and ventral neural tube,, leading to neural… (More)
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Highly Cited
1996
Highly Cited
1996
Targeted gene disruption in the mouse shows that the Sonic hedgehog(Shh) gene plays a critical role in patterning of vertebrate… (More)
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Highly Cited
1993
Highly Cited
1993
Here, we report the cloning of a cDNA from zebrafish encoding a member of the fork head/HNF3 gene family. The gene, which we have… (More)
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