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Monogenic Obesity

Obesity associated with an identifiable mutation in a single gene.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2018
05101519962018

Papers overview

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Review
2015
Review
2015
Obesity genetics in mouse and human: back and forth, and back again
Obesity is a major public health concern. This condition results from a constant and complex interplay between predisposing genes… (More)
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2012
2012
Obesity-programmed mice are rescued by early genetic intervention.
Obesity is a chronic metabolic disorder affecting half a billion people worldwide. Major difficulties in managing obesity are the… (More)
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2010
2010
Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression.
Single-minded 1 (SIM1) mutations are one of the few known causes of nonsyndromic monogenic obesity in both humans and mice… (More)
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Highly Cited
2010
Highly Cited
2010
TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.
Primary cilia function as a sensory signaling compartment in processes ranging from mammalian Hedgehog signaling to neuronal… (More)
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Highly Cited
2008
Highly Cited
2008
Common nonsynonymous variants in PCSK1 confer risk of obesity
Mutations in PCSK1 cause monogenic obesity. To assess the contribution of PCSK1 to polygenic obesity risk, we genotyped tag SNPs… (More)
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Highly Cited
2008
Highly Cited
2008
Regulation of Fto/Ftm gene expression in mice and humans.
Two recent, large whole-genome association studies (GWAS) in European populations have associated a approximately 47-kb region… (More)
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Highly Cited
2007
Highly Cited
2007
Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene.
The melanocortin-4 receptor (MC4R) gene pathogenic mutations are the most prevalent forms of monogenic obesity, responsible for… (More)
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Highly Cited
2003
Highly Cited
2003
Binge eating as a major phenotype of melanocortin 4 receptor gene mutations.
BACKGROUND Obesity, a multifactorial disease caused by the interaction of genetic factors with the environment, is largely… (More)
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2000
2000
Pseudohypoparathyroidism--another monogenic obesity syndrome.
Obesity is a common feature of pseudohypoparathyroidism (PHP) type 1a, but is usually associated with short stature. We describe… (More)
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1997
1997
A new class of obesity genes encodes leukocyte adhesion receptors.
Obesity is a complex disease, and multiple genes contribute to the trait. The description of five genes (ob, db, tub, Ay, and fat… (More)
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