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Monogenic Obesity

Obesity associated with an identifiable mutation in a single gene.
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Distinguishing patients with monogenic diabetes from those with type 1 diabetes (T1D) is important for correct diagnosis… Expand
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Highly Cited
2013
Highly Cited
2013
Because of the unbalanced sex ratio (1.3-1.4 to 1) observed in intellectual disability (ID) and the identification of large ID… Expand
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Highly Cited
2009
Highly Cited
2009
The incidence and prevalence of type 2 diabetes (T2D) continue to escalate at an unprecedented rate in the United States… Expand
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Highly Cited
2008
Highly Cited
2008
Mutations in PCSK1 cause monogenic obesity. To assess the contribution of PCSK1 to polygenic obesity risk, we genotyped tag SNPs… Expand
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Highly Cited
2008
Highly Cited
2008
Two recent, large whole-genome association studies (GWAS) in European populations have associated a approximately 47-kb region… Expand
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Highly Cited
2007
Highly Cited
2007
The melanocortin-4 receptor (MC4R) gene pathogenic mutations are the most prevalent forms of monogenic obesity, responsible for… Expand
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Review
2005
Review
2005
The clinical picture of type 2 diabetes mellitus (T2DM) is formed by impairment in insulin secretion and resistance to insulin… Expand
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Highly Cited
2005
Highly Cited
2005
We have isolated phytochrome B (phyB) and phyC mutants from rice (Oryza sativa) and have produced all combinations of double… Expand
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Review
2005
Review
2005
The idiopathic generalized epilepsies (IGEs) are considered to be primarily genetic in origin. They encompass a number of rare… Expand
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Highly Cited
1998
Highly Cited
1998
Elevated blood plasma cholesterol (hypercholesterolemia) is a major risk factor for coronary artery disease (CAD) in humans… Expand
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