Monogenic Obesity

Obesity associated with an identifiable mutation in a single gene.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2018
05101519962018

Papers overview

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Review
2015
Review
2015
Obesity is a major public health concern. This condition results from a constant and complex interplay between predisposing genes… (More)
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2012
2012
Obesity is a chronic metabolic disorder affecting half a billion people worldwide. Major difficulties in managing obesity are the… (More)
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2010
2010
Single-minded 1 (SIM1) mutations are one of the few known causes of nonsyndromic monogenic obesity in both humans and mice… (More)
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Highly Cited
2010
Highly Cited
2010
Primary cilia function as a sensory signaling compartment in processes ranging from mammalian Hedgehog signaling to neuronal… (More)
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Highly Cited
2008
Highly Cited
2008
Mutations in PCSK1 cause monogenic obesity. To assess the contribution of PCSK1 to polygenic obesity risk, we genotyped tag SNPs… (More)
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Highly Cited
2008
Highly Cited
2008
Two recent, large whole-genome association studies (GWAS) in European populations have associated a approximately 47-kb region… (More)
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Highly Cited
2007
Highly Cited
2007
The melanocortin-4 receptor (MC4R) gene pathogenic mutations are the most prevalent forms of monogenic obesity, responsible for… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Obesity, a multifactorial disease caused by the interaction of genetic factors with the environment, is largely… (More)
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2000
2000
Obesity is a common feature of pseudohypoparathyroidism (PHP) type 1a, but is usually associated with short stature. We describe… (More)
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1997
1997
Obesity is a complex disease, and multiple genes contribute to the trait. The description of five genes (ob, db, tub, Ay, and fat… (More)
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