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Monogenic Obesity

Obesity associated with an identifiable mutation in a single gene.
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Distinguishing patients with monogenic diabetes from those with type 1 diabetes (T1D) is important for correct diagnosis… 
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Highly Cited
2013
Highly Cited
2013
Because of the unbalanced sex ratio (1.3-1.4 to 1) observed in intellectual disability (ID) and the identification of large ID… 
Review
2013
Review
2013
Obesity is a disorder characterized by an excess accumulation of body fat resulting from a mismatch between energy intake and… 
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Review
2010
Review
2010
  • Y. Tao
  • Endocrine reviews
  • 2010
  • Corpus ID: 36617488
The melanocortin-4 receptor (MC4R) was cloned in 1993 by degenerate PCR; however, its function was unknown. Subsequent studies… 
Highly Cited
2009
Highly Cited
2009
The incidence and prevalence of type 2 diabetes (T2D) continue to escalate at an unprecedented rate in the United States… 
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Highly Cited
2008
Highly Cited
2008
Mutations in PCSK1 cause monogenic obesity. To assess the contribution of PCSK1 to polygenic obesity risk, we genotyped tag SNPs… 
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Review
2005
Review
2005
  • M. Małecki
  • Diabetes research and clinical practice
  • 2005
  • Corpus ID: 20698785
The clinical picture of type 2 diabetes mellitus (T2DM) is formed by impairment in insulin secretion and resistance to insulin… 
Highly Cited
2005
Highly Cited
2005
We have isolated phytochrome B (phyB) and phyC mutants from rice (Oryza sativa) and have produced all combinations of double… 
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Review
2005
Review
2005
Summary:  The idiopathic generalized epilepsies (IGEs) are considered to be primarily genetic in origin. They encompass a number… 
Highly Cited
1998
Highly Cited
1998
Elevated blood plasma cholesterol (hypercholesterolemia) is a major risk factor for coronary artery disease (CAD) in humans…