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The SLC6A14 gene shows evidence of association with obesity.
In our previous genome-wide scan of Finnish nuclear families, obesity was linked to chromosome Xq24. Here we analyzed this 15-Mb region by genotyping 9 microsatellite markers and 36 single nucleotideExpand
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  • Open Access
A male-specific quantitative trait locus on 1p21 controlling human stature
Background: Many genome-wide scans aimed at complex traits have been statistically underpowered due to small sample size. Combining data from several genome-wide screens with comparable quantitativeExpand
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  • Open Access
Further Evidence For the Role of ENPP1 in Obesity: Association With Morbid Obesity in Finns
The aim of this study was to investigate a series of single‐nucleotide polymorphisms (SNPs) in the genes MC2R, MC3R, MC4R, MC5R, POMC, and ENPP1 for association with obesity. Twenty‐five SNPs (2–7Expand
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Pro-opiomelanocortin gene is associated with serum leptin levels in lean but not in obese individuals
OBJECTIVE: Mutations in the pro-opiomelanocortin and melanocortin 4 receptor genes (POMC and MC4R) cause monogenic obesity, and the POMC locus (2p21) has been linked to leptin levels and body massExpand
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Common Hepatic Nuclear Factor-4α Variants Are Associated With High Serum Lipid Levels and the Metabolic Syndrome
Hepatic nuclear factor-4α (HNF-4α), a transcription factor involved in the regulation of serum lipid and glucose levels, has recently been associated with type 2 diabetes. The HNF-4α gene (HNF4A)Expand
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Unraveling the complex genetics of familial combined hyperlipidemia
Familial combined hyperlipidemia (FCHL) constitutes a substantial risk factor for atherosclerosis since it is observed in about 20% of coronary heart disease (CHD) patients under 60 years. FCHL,Expand
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Locus for quantitative HDL-cholesterol on chromosome 10q in Finnish families with dyslipidemia Published, JLR Papers in Press, July 16, 2004. DOI 10.1194/jlr.M400141-JLR200
Decreased HDL-cholesterol (HDL-C) and familial combined hyperlipidemia (FCHL) are the two most common familial dyslipidemias predisposing to premature coronary heart disease (CHD). TheseExpand
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IFNγ production by NK cells from HLA-sensitized patients after in vitro exposure to allo-antigens.
Using a novel cytokine flow cytometry test (allo-CFC), we have previously shown that incubation of allogeneic cells with peripheral blood from highly-HLA sensitized (HS) patients results inExpand
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Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection.
INTRODUCTION Antibody-mediated rejection (ABMR) is dependent on complement activating donor-specific anti-HLA antibodies (DSA). This is commonly detected by C4d deposition in allografts. However,Expand
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Significant Reduction of ATP Production in PHA-Activated CD4+ Cells in 1-Day-Old Blood from Transplant Patients
Background Global immunosuppression can be measured by assessing adenosine triphospate (ATP) levels in mitogen-stimulated CD4+ T cells. Methods We investigated the effect of storage time on ATPExpand
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