Molsidomine

Known as: Sydnone imine, N-(ethoxycarbonyl)-3-(4-morpholinyl)-, Morsydomine, Molsidomin 
A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has… (More)
National Institutes of Health

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2013
2013
BACKGROUND AND AIMS Despite its beneficial effects, cisplatin has considerable nephrotoxic, ototoxic, neurotoxic and hepatotoxic… (More)
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2005
2005
BACKGROUND Nitric oxide (NO), synthesized from L-arginine by the enzyme NO synthase (NOS) seems to play an ambiguous role during… (More)
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2005
2005
Spontaneously hypertensive rats (SHR) have a higher level of oxidative stress and exhibit a greater depressor response to a… (More)
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2005
2005
The effects of the nitric oxide (NO) donor molsidomine on aged rats' cognition were evaluated in two different behavioral tasks… (More)
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Highly Cited
2004
Highly Cited
2004
Modern medicine faces the challenge of developing safer and more effective therapies to treat human diseases. Many drugs… (More)
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2004
2004
Ischemia reperfusion (I-R)-induced renal damage is reduced by systemic administration of the NO-dependent vasodilator molsidomine… (More)
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2001
2001
Nitric oxide (NO) is hypothesized to be a novel intracellular messenger in the central nervous system. Recently, NO involvement… (More)
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1996
1996
Molsidomine is a prodrug for the formation of nitric oxide (NO). Its pharmacokinetics are characterised by rapid absorption and… (More)
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1985
1985
Molsidomine is enzymatically metabolized in the liver to SIN-1 and readily converted into the active metabolite SIN-1A, which… (More)
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1980
1980
Molsidomine, a new long-acting vasodilator, was administered intravenously (0.03 mg per kilogram of body weight) to two groups of… (More)
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