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MitoTEMPO

National Institutes of Health

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Organophosphorus CompoundsPiperidines

Papers overview

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2020
2020
Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity
In cancer cells, aerobic glycolysis rather than oxidative phosphorylation (OxPhos) is generally preferred for the production of… 
2020
2020
TARGETING HUMAN LUNG ADENOCARCINOMA WITH A SUPPRESSOR OF MITOCHONDRIAL SUPEROXIDE PRODUCTION.
AIMS REDOX signaling from reactive oxygen species generated by the mitochondria (mtROS) has been implicated in cancer growth and… 
2019
2019
Comparative study on isolation and mitochondrial function of adult mouse and rat cardiomyocytes.
2019
2019
FOXO3a regulates rhinovirus-induced innate immune responses in airway epithelial cells
Forkhead transcription factor class O (FOXO)3a, which plays a critical role in a wide variety of cellular processes, was also… 
2019
2019
Simvastatin Mitigates Apoptosis and Transforming Growth Factor-Beta Upregulation in Stretch-Induced Endothelial Cells
Portal hypertension is a common clinical symptom of digestive disorders. With an increase in portal pressure, the portal vein… 
2018
2018
Reduced intestinal epithelial mitochondrial function enhances in vitro interleukin-8 production in response to commensal Escherichia coli
Uncoupling of oxidative phosphorylation in epithelial mitochondria results in decreased epithelial barrier function as… 
2018
2018
Rubella Virus Strain-Associated Differences in the Induction of Oxidative Stress Are Independent of Their Interferon Activation
Rubella virus (RV) infection impacts cellular metabolic activity in a complex manner with strain-specific nutritional… 
2017
2017
Downregulation of IDH2 exacerbates H2O2-mediated cell death and hypertrophy
Objectives: Reactive oxygen species-mediated cell death contributes to the pathophysiology of cardiovascular disease and… 
2015
2015
Vicious inducible nitric oxide synthase-mitochondrial reactive oxygen species cycle accelerates inflammatory response and causes liver injury in rats.
AIMS Increasing evidences suggest that, apart from activation of guanylyl cyclase, intracellular nitric oxide (NO) signaling is… 
2009
2009
Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells
Reactive oxygen species (ROS) contribute significantly to apoptosis in renal ischemia-reperfusion (IR) injury, however the exact… 
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