Mice, Jimpy

Jimpy is a shortened life-span murine mutant whose genetic disorder results in a severe hypomyelination in the central neruons… (More)

Mutations in genes encoding membrane proteins have been associated with cell death of unknown cause from invertebrate development… (More)

Mutations in the myelin proteolipid protein (PLP) gene, such as that found in the jimpy mouse, result in an abnormal structure of… (More)

Intense and specific immunostaining of oligodendrocytes in vivo has been obtained for the first time using antibodies to… (More)

Gliosis is a common phenomenon which occurs in many human diseases and in experimentally altered nervous tissue. The factors… (More)

Neuroglial cell death was investigated in 3 white matter tracts of jimpy and normal mice. In normal animals, glial death during… (More)

Mutations affecting developmental processes may allow some insight into the complexity of the biological processes involved. In… (More)

A clone specific for the rat myelin proteolipid protein (PLP) was isolated from a cDNA library made in pUC18 from 17-day-old rat… (More)

We have observed focal axonal enlargements in jimpy, a myelin deficient mutant mouse. Similar axonal swellings have also been… (More)

Glial development was studied in the optic nerve of 1- to 28-day-old Jimpy mice and controls. Abnormalities were found in… (More)