Mice, Jimpy

Missense mutations in the human PLP1 gene lead to dysmyelinating diseases with a broad range of clinical severity, ranging from… Expand

Jimpy is a genetic disorder which results in a severe hypomyelination in the central nervous system associated with a variety of… Expand

The jimpy rumpshaker (jprsh) mutation is an amino acid substitution in exon 4 (Ile186-->Thr) of the proteolipid protein (PLP… Expand

Astrogliosis is a prominent feature in the CNS of the dysmyelinating mutant, jimpy. In the following study the expression of the… Expand

The broad background resonance observed in the in vivo 31P NMR spectra of adult murine heads was investigated in terms of… Expand

Gliosis is a common phenomenon which occurs in many human diseases and in experimentally altered nervous tissue. The factors… Expand

We have observed focal axonal enlargements in jimpy, a myelin deficient mutant mouse. Similar axonal swellings have also been… Expand

The topographical distribution of myelin basic protein (MBP) and of glial fibrillary acidic protein (GFA) have been compared in… Expand

Abstract The Jimpy mouse is a sex-linked recessive mutant characterized by a paucity of myelin in the Central Nervous System… Expand

— The activity of plasmalogenase, which hydrolyzes the vinyl ether linkage of the plasmalogen molecule, increased markedly in… Expand