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Methylating Agent [EPC]

Known as: Methylating Agent 
 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
The DNA adduct O6-methylguanine (O6MeG) induced by environmental genotoxins and anticancer drugs is a highly mutagenic, genotoxic… Expand
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Temozolomide (TMZ), an oral methylating imidazotetrazinone, has antitumor activity against gliomas, malignant… Expand
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2005
2005
Methylating agents of the SN1 type represent an important class of cancer chemotherapeutics. Efficient killing by clinically… Expand
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Highly Cited
2004
Highly Cited
2004
S(N)1-type alkylating agents represent an important class of chemotherapeutics, but the molecular mechanisms underlying their… Expand
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Highly Cited
1998
Highly Cited
1998
Temozolomide, a methylating imidazotetrazinone, has antitumor activity against gliomas, malignant melanoma, and mycosis fungoides… Expand
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1997
1997
During reverse transcription of retroviral RNA, synthesis of (-) strand DNA is primed by a cellular tRNA that anneals to an 18-nt… Expand
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Highly Cited
1996
Highly Cited
1996
Depletion of the DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (AGT) with O(6)-benzylguanine (O(6)-BG) has been… Expand
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Highly Cited
1994
Highly Cited
1994
The hypothesis that the antitumor prodrug temozolomide is ring-opened to MTIC which then further breaks down to a reactive… Expand
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1985
1985
The activity of phosphatidylethanolamine N-methyltransferase (PeMT), an enzymic system that catalyses the synthesis of… Expand
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1979
1979
Mutation to 8-azaguanine resistance in Chinese hamster cells and cytotoxicity and production and repair of alkalilabile lesions… Expand
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