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Methylating Agent [EPC]

Known as: Methylating Agent 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
The DNA adduct O6-methylguanine (O6MeG) induced by environmental genotoxins and anticancer drugs is a highly mutagenic, genotoxic… Expand
Highly Cited
2008
Highly Cited
2008
Temozolomide (TMZ), an oral methylating imidazotetrazinone, has antitumor activity against gliomas, malignant melanomas, and… Expand
2005
2005
Methylating agents of the SN1 type represent an important class of cancer chemotherapeutics. Efficient killing by clinically… Expand
Highly Cited
2004
Highly Cited
2004
S(N)1-type alkylating agents represent an important class of chemotherapeutics, but the molecular mechanisms underlying their… Expand
Highly Cited
1998
Highly Cited
1998
Temozolomide, a methylating imidazotetrazinone, has antitumor activity against gliomas, malignant melanoma, and mycosis fungoides… Expand
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Highly Cited
1996
Highly Cited
1996
Depletion of the DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (AGT) with O(6)-benzylguanine (O(6)-BG) has been… Expand
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Highly Cited
1994
Highly Cited
1994
The hypothesis that the antitumor prodrug temozolomide is ring-opened to MTIC which then further breaks down to a reactive… Expand
Highly Cited
1985
Highly Cited
1985
The activity of phosphatidylethanolamine N-methyltransferase (PeMT), an enzymic system that catalyses the synthesis of… Expand
1979
1979
Mutation to 8-azaguanine resistance in Chinese hamster cells and cytotoxicity and production and repair of alkalilabile lesions… Expand
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1977
1977
We reported earlier that the methylation of unmethylated reovirus mRNA (reo mRNAU) by the cellular methylating enzymes is… Expand
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