Methylating Agent [EPC]

Known as: Methylating Agent 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1979-2010
012319792010

Papers overview

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2010
2010
The DNA adduct O(6)-methylguanine (O(6)MeG) induced by environmental genotoxins and anticancer drugs is a highly mutagenic… (More)
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2008
2008
BACKGROUND Temozolomide (TMZ), an oral methylating imidazotetrazinone, has antitumor activity against gliomas, malignant… (More)
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2005
2005
Methylating agents of the SN1 type represent an important class of cancer chemotherapeutics. Efficient killing by clinically… (More)
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Highly Cited
2004
Highly Cited
2004
S(N)1-type alkylating agents represent an important class of chemotherapeutics, but the molecular mechanisms underlying their… (More)
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Highly Cited
1998
Highly Cited
1998
Temozolomide, a methylating imidazotetrazinone, has antitumor activity against gliomas, malignant melanoma, and mycosis fungoides… (More)
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1997
1997
During reverse transcription of retroviral RNA, synthesis of (-) strand DNA is primed by a cellular tRNA that anneals to an 18-nt… (More)
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1996
1996
Depletion of the DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (AGT) with O(6)-benzylguanine (O(6)-BG) has been… (More)
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Highly Cited
1994
Highly Cited
1994
The hypothesis that the antitumor prodrug temozolomide is ring-opened to MTIC which then further breaks down to a reactive… (More)
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1985
1985
The activity of phosphatidylethanolamine N-methyltransferase (PeMT), an enzymic system that catalyses the synthesis of… (More)
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1981
1981
The mutagenic activities of a diverse group of N-nitrosamines were measured in Salmonella typhimurium TA 100 under conditions… (More)
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