Metastatic Squamous Cell Carcinoma

A squamous cell carcinoma which has spread from its original site of growth to another anatomic site.
National Institutes of Health

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Epithelial CellsEpitheliumMalignant Epithelial CellNeoplastic Cell
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Papers overview

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Highly Cited
2011
Highly Cited
2011
Evaluation of EGFR gene copy number as a predictive biomarker for the efficacy of cetuximab in combination with chemotherapy in the first-line treatment of recurrent and/or metastatic squamous cell…
BACKGROUND The phase III EXTREME study demonstrated that combining cetuximab with platinum/5-fluorouracil (5-FU) significantly… (More)
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Highly Cited
2009
Highly Cited
2009
Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck [corrected].
PURPOSE To compare survival in patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) treated… (More)
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Highly Cited
2009
Highly Cited
2009
Cetuximab plus cisplatin-5-fluorouracil versus cisplatin-5-fluorouracil alone in first-line metastatic squamous cell carcinoma of the esophagus: a randomized phase II study of the Arbeitsgemeinschaft…
BACKGROUND This study assessed the activity of the mAb cetuximab in combination with cisplatin and 5-fluorouracil (5-FU) in… (More)
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Highly Cited
2007
Highly Cited
2007
Phase II trial of sorafenib in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or nasopharyngeal carcinoma.
PURPOSE To determine the efficacy and safety of single-agent sorafenib in patients with recurrent and/or metastatic squamous cell… (More)
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Highly Cited
2007
Highly Cited
2007
Detection of human papillomavirus-16 in fine-needle aspirates to determine tumor origin in patients with metastatic squamous cell carcinoma of the head and neck.
PURPOSE Patients with head and neck squamous cell carcinoma (HNSCC) often clinically present with metastases to regional lymph… (More)
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Highly Cited
2005
Highly Cited
2005
Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study.
PURPOSE Therapy of recurrent/metastatic squamous cell carcinoma of the head and neck results in median progression-free survival… (More)
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Highly Cited
2005
Highly Cited
2005
Phase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinum-refractory metastatic…
PURPOSE To evaluate the efficacy and safety of the antiepidermal growth factor receptor monoclonal antibody cetuximab in… (More)
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Highly Cited
2005
Highly Cited
2005
Phase II trial of gefitinib 250 mg daily in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck.
PURPOSE An objective response rate of 11% was reported in patients with recurrent and/or metastatic squamous cell carcinoma of… (More)
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Highly Cited
2003
Highly Cited
2003
Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck.
PURPOSE The epidermal growth factor receptor (EGFR) is a mediator of squamous cell carcinoma of the head and neck (SCCHN… (More)
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1995
1995
Cystic change in lymph nodes with metastatic squamous cell carcinoma.
A retrospective analysis was performed of the gross characteristics of aspirated material in 335 consecutive cases of metastatic… (More)
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