Skip to search formSkip to main contentSkip to account menu

Merestinib

Known as: 3-Pyridinecarboxamide, N-(3-fluoro-4-((1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-1,2-dihydro-6-methyl-2-oxo- 
An orally available, small molecule inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor (HGFR)) with potential… 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

LY2801653
NCIt Antineoplastic Agent TerminologyReceptor Tyrosine Kinase Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Augmenting nab-paclitaxel/gemcitabine standard chemotherapy response by merestinib, an inhibitor of c-MET, Axl and DDR signaling pathways, in preclinical pancreatic cancer models
Background and Hypothesis: Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal malignancies in Western countries… 
2018
2018
Acquired resistance to AZD9291 as an upfront treatment is dependent on ERK signaling in a preclinical model
AZD9291 (osimertinib) is approved for standard care in patients with EGFR T790M-positive non-small cell lung cancer (NSCLC) after… 
2018
2018
Abstract CT018: Interim safety and clinical activity in patients (pts) with advanced refractory solid tumors from a phase Ia/b study investigating the novel anti-PD-L1 antibody (LY3300054…
Background: PD-L1 expression is associated with reduced survival and an unfavorable prognosis in a wide range of cancers… 
2017
2017
Gemcitabine and cisplatin plus ramucirumab or merestinib or placebo in first-line treatment for advanced or metastatic biliary tract cancer: A double-blind, randomized phase II trial.
TPS509Background: Angiogenesis and aberrant MET signaling are implicated in the pathogenesis and progression of invasive biliary… 
2016
2016
The discovery and the structural basis of an imidazo[4,5-b]pyridine-based p21-activated kinase 4 inhibitor.
2016
2016
MNK Inhibition Disrupts Mesenchymal Glioma Stem Cells and Prolongs Survival in a Mouse Model of Glioblastoma
Glioblastoma multiforme remains the deadliest malignant brain tumor, with glioma stem cells (GSC) contributing to treatment… 
2016
2016
Abstract 2647: Merestinib (LY2801653), targeting several oncokinases including NTRK1/2/3, shows potent anti-tumor effect in colorectal cell line- and patient-derived xenograft (PDX) model bearing…
In cancer, the formation of chimeric gene fusions by genomic rearrangement causes aberrant receptor tyrosine kinase activation… 
2016
2016
MET inhibition and merestinib (LY-2801653) for cancer treatment
2013
2013
Dérivés de 5-(1h-pyrazol-4-yl)-1h-pyrrolo[2,3-b]pyridine utilisés comme inhibiteurs de kinases
La presente invention porte sur de nouveaux derives de 5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine de formule (I), utilises… 
2013
2013
Synthesis and Characterization of N-aryl Maleimide Derivatives
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)