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Menogaril

Known as: 7-O-Methylnogarol, 7-con-O-methylnorgarol, Menogaril [Chemical/Ingredient] 
A semisynthetic derivative of the anthracycline antineoplastic antibiotic nogalamycin. Menogaril intercalates into DNA and interacts with… 
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (5)

7-deoxynogarolN-demethylmenogarilNSC-269148TUT-7

Broader (1)

Antibiotics, Antineoplastic
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Menogaril: a new anthracycline agent entering clinical trials
SummaryMenogaril [menogarol, 7(R)-O-methymogarol, 7-OMEN] is a new anthracycline agent which was chosen for clinical trials based… 
Highly Cited
1989
Highly Cited
1989
In vitro evaluation of the new anticancer agents KT6149, MX-2, SM5887, menogaril, and liblomycin using cisplatin- or adriamycin-resistant human cancer cell lines.
A new model to predict antitumor activity of new analogues was developed, and the cross-resistance against cisplatin (CDDP) and… 
Highly Cited
1986
Highly Cited
1986
Human pharmacokinetics, excretion, and metabolism of the anthracycline antibiotic menogaril (7-OMEN, NSC 269148) and their correlation with clinical toxicities.
In a Phase I study, menogaril (7-OMEN) was administered daily for 5 days/course, every 21-28 days. Dosages of 3.5, 7, 11.5, 17… 
1983
1983
Comparative genotoxicity of adriamycin and menogarol, two anthracycline antitumor agents.
Adriamycin and menogarol are anthracyclines which cause more than 100% increase in life span of mice bearing P388 leukemia and… 
1981
1981
Effect of 7-con-O-methylnogarol on DNA synthesis, survival, and cell cycle progression of Chinese hamster ovary cells.
The effect of 7-con-O-methylnogarol (7-OMEN) on the survival of exponentially growing and plateau-phase Chinese hamster ovary… 
1980
1980
Lethality of nogalamycin, nogalamycin analogs, and adriamycin to cells in different cell cycle phases.
The drugs studied included nogalamycin and its derivative 7-con-O-methylnogalarol, dis-nogamycin and its derivative 7-con-O… 
1979
1979
Treatment of mouse tumors with 7-con-O-methylnogarol and other analogs of the anthracycline antibiotic, nogalamycin.
: The chemotherapeutic activity of analogs of the anthracycline antibiotic, nogalamycin, was investigated in the P388 and L1210… 
1979
1979
Chronic cardiotoxicity studies in rabbits with 7-con-O-methylnogarol, a new anthracycline antitumor agent.
Abstract 7- con-O -Methylnogarol (7-OMEN), a new analog of the anthracycline antibiotic, nogalamycin, has chemotherapeutic… 
1979
1979
Treatment of mouse tumors with 7-con-O-methylnogarol and other analogs of the anthracycline antibiotic, nogalamycin.
The chemotherapeutic activity of analogs of the anthracycline antibiotic, nogalamycin, was investigated in the P388 and L1210… 
1979
1979
Improved antitumor activity by modification of nogalamycin.
Nogalamycin, an antitumor antibiotic, has been converted to a series of analogs by removal of the carbomethoxy group at C-10 and… 
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