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Bacterial mutagenicity and mammalian cell DNA damage by several substituted anilines.
Several substituted alkyl- and haloanilines were tested for their ability to mutate Salmonella typhimurium and to damage the DNA of mammalian (V79) cells. These results were correlated with theirExpand
Spontaneous mutation spectrum at the lambda cII locus in liver, lung, and spleen tissue of Big Blue® transgenic mice
TLDR
The cII/cI system is insensitive to deletion events, but is useful for detecting point mutations, and the in vivo cII spectrum had a significantly higher proportion of G → A and G → T mutations and fewer frameshifts than reported in vitro. Expand
Mammalian host- and fluid-mediated mutagenicity assays of captan and streptozotocin in Salmonella typhimurium.
TLDR
The results of the experiments suggested that captan's mutagenicity is probably inactivated by glutathione of the erythrocytes, and inactivated more efficiently than of SZN by blood. Expand
Comparison of mutant frequencies at the transgenic lambda lacI and cII/cI loci in control and ENU‐treated Big Blue® mice
TLDR
The cII/cI assay may be an acceptable alternative to lacI where transgenic mutation studies are indicated and overall results were similar for the two mutational endpoints. Expand
The mouse bone marrow micronucleus test: evaluation of 21 drug candidates.
TLDR
The mouse bone-marrow micronucleus test is one of the most widely used genetic toxicology assays, and 3 potential chemotherapeutic agents were identified as strongly clastogenic and one compound was identified as a weak inducer of micronsi in the assay. Expand
DNA sequence analysis of spontaneous hprt mutations arising in vivo in cynomolgus monkey T‐lymphocytes
TLDR
The spectrum of spontaneous hprt mutations arising in vivo in wild‐caught cynomolgus monkey peripheral T‐lymphocytes is described and 40 spontaneous mutants from 11 monkeys are sequenced. Expand
Mutagenicity of streptozotocin and several other nitrosourea compounds in Salmonella typhimurium.
TLDR
Nitrosourea compounds compared for their ability to induce mutation in the histidine-requiring auxotroph Salmonella typhimurium his G46 are shown to be highly mutagenic. Expand
Enumeration of 6‐thioguanine‐resistant T‐lymphocytes in the peripheral blood of nonhuman primates (cynomolgus monkeys)
TLDR
The TG‐resistant phenotype of clones isolated in the assay was stable after growth for 2 weeks in the absence of selective agent, and many of the TG‐ resistant clones selected were frozen for future molecular analysis. Expand
Culture and propagation of Hprt mutant T‐lymphocytes isolated from mouse spleen
TLDR
Rat T‐STIMTM‐supplemented medium enhances the initial outgrowth of mouse T‐cells, and repeated mitogenic stimulation with Con A in the presence of IL‐2 and rat T‐ STIMTM provides a means for propagatingmouse T‐cell clones for mutation analyses by a variety of methods. Expand
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