Skip to search formSkip to main contentSkip to account menu

Maximum Tolerated Dose

Known as: Maximum Tolerated Doses, Doses, Maximum Tolerated, Tolerated Doses, Maximum 
The highest dose of a drug or treatment that does not cause unacceptable side effects. The maximum tolerated dose is determined in clinical trials by… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
P1-12-19: Phase I Study of Single Agent Trastuzumab Emtansine in Japanese Patients with Human Epidermal Growth Factor Receptor2 (HER2)-Positive Metastatic Breast Cancer (JO22591).
Background Trastuzumab emtansine (T-DM1), first-in-class anti-HER2 antibody-drug conjugate (ADC) is under development for the… 
2010
2010
The toxic effect of intravenous application of the trypanocide isometamidium (Samorin).
Summary For the trypanocide isometamidium chloride (Samorin®, May & Baker) the intramuscular route is recommended by the… 
2008
2008
Phase I multicenter trial of perifosine in combination with sorafenib for patients with advanced cancers including renal cell carcinoma
16024 Background: Perifosine (PERI) is an oral alkylphosphocholine with effects on multiple pathways including Akt, MAPK and JNK… 
2004
2004
CB 1954 revisited
SummaryAlthough it has been the subject of considerable interest for 15 years, originally as a cytotoxic agent and more recently… 
2004
2004
Elektronenmikroskopische Untersuchungen über Glaskörperrindenzellen und Zonulafasern
SummaryThe following electron microscopical findings in the vitreous body of 16-day-old rat embryos and in the vitreoretinal… 
2004
2004
A Phase I/II Study of the Oral mTOR Inhibitor RAD001 in Patients with Advanced Hematologic Malignancies
2003
2003
Pathogen inactivation of RBCs: PEN110 reproductive toxicology studies
BACKGROUND:  The novel PEN110 chemistry (INACTINE, V.I. Technologies) process for the purification of blood for transfusions… 
1995
1995
Dose escalation study of high-dose carboplatin and etoposide with autologous bone marrow support in patients with recurrent and refractory germ cell tumors.
Thirty-three patients with germ cell cancer (GCT) recurrent after two cisplatin-based regimens or cisplatin refractory… 
Highly Cited
1980
Highly Cited
1980
Maximal Tolerated Insulin Therapy in Gestational Diabetes
Beginning in 1963 we have administered fast-acting insulin in three daily injections up to the maximal tolerated dose (M.T.D… 
1980
1980
Effect of treatment with 1-beta-D-arabinofuranosylthymine of experimental encephalitis induced by herpes simplex virus in mice
1-beta-D-Arabinofuranosylthymine (ara-T) was examined for its therapeutic efficacy against encephalitis in mice inoculated…