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Maximum Tolerated Dose

Known as: Maximum Tolerated Doses, Doses, Maximum Tolerated, Tolerated Doses, Maximum 
The highest dose of a drug or treatment that does not cause unacceptable side effects. The maximum tolerated dose is determined in clinical trials by… 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Phase I trial of UCN-01 in combination with topotecan in patients with advanced solid cancers: a Princess Margaret Hospital Phase II Consortium study.
BACKGROUND 7-Hydroxystaurosporine (UCN-01) inhibits serine-threonine kinases including the Ca2+ and phospholipid-dependent… 
Highly Cited
2004
Highly Cited
2004
Phase I trial of weekly docetaxel with concurrent three-dimensional conformal radiation therapy in the treatment of unfavorable localized adenocarcinoma of the prostate.
PURPOSE A phase I trial was conducted to determine the maximally tolerated dose (MTD) of concurrent weekly docetaxel and three… 
Highly Cited
1995
Highly Cited
1995
Quick estimate of the regulatory virtually safe dose based on the maximum tolerated dose for rodent bioassays.
  • D. GaylorL. Gold
  • Regulatory toxicology and pharmacology : RTP
  • 1995
  • Corpus ID: 7751239
With a limited subset of National Cancer Institute/National Toxicology Program (NCI/NTP) bioassays, Gaylor (Regul. Toxicol… 
1994
1994
Lack of neurotoxicity of oral bisacetatoamminedichlorocyclohexylamine-platinum(IV) in comparison to cisplatin and tetraplatin in the rat.
This study compared the effect on sensory nerve conduction velocity in the hind limb of chronically treated age-matched rats of a… 
1993
1993
Structural relationships between mutagenicity, maximum tolerated dose, and carcinogenicity in rodents
The CASE structure‐activity relational system was applied to a study of the structural bases of toxicity as expressed in the… 
Highly Cited
1989
Highly Cited
1989
Prenatal or postnatal exposure to bis(tri-n-butyltin)oxide in the rat: postnatal evaluation of teratology and behavior.
Highly Cited
1987
Highly Cited
1987
Total body irradiation and high-dose etoposide: a new preparatory regimen for bone marrow transplantation in patients with advanced hematologic malignancies [published erratum appears in Blood 1987…
In a phase I/II study, 47 patients (median age, 24 years) with hematologic malignancies (33 patients with acute leukemia not in… 
Highly Cited
1985
Highly Cited
1985
Phase I pharmacologic study of a new Vinca alkaloid: navelbine.
Highly Cited
1982
Highly Cited
1982
Clinical trials of WR-2721 with radiation therapy.
Highly Cited
1980
Highly Cited
1980
Maximal Tolerated Insulin Therapy in Gestational Diabetes
Beginning in 1963 we have administered fast-acting insulin in three daily injections up to the maximal tolerated dose (M.T.D… 
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