Maximum Tolerated Dose

Known as: Maximum Tolerated Doses, Doses, Maximum Tolerated, Tolerated Doses, Maximum 
The highest dose of a drug or treatment that does not cause unacceptable side effects. The maximum tolerated dose is determined in clinical trials by… (More)

Topic mentions per year

Topic mentions per year

1950-2017
020040019502016

Papers overview

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Highly Cited
2010
Highly Cited
2010
BACKGROUND Olaparib, a novel, orally active poly(ADP-ribose) polymerase (PARP) inhibitor, induced synthetic lethality in BRCA… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Curcumin is the major yellow pigment extracted from turmeric, a commonly-used spice in India and Southeast Asia that… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE A transgenic mouse model has revealed parameters of the angiogenic switch during multistep tumorigenesis of pancreatic… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE To investigate the maximum tolerated dose of ranibizumab administered as a single intravitreal injection. DESIGN Open… (More)
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Highly Cited
2004
Highly Cited
2004
Hydroxyurea improves hematologic parameters for children with sickle cell disease (SCD), but its long-term efficacy at maximum… (More)
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Highly Cited
2003
Highly Cited
2003
Chemotherapeutic drugs chronically administered to tumor-bearing mice, using a frequent schedule at doses substantially lower… (More)
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Highly Cited
2002
Highly Cited
2002
Thalidomide (Thal) can overcome drug resistance in multiple myeloma (MM) but is associated with somnolence, constipation, and… (More)
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Highly Cited
2001
Highly Cited
2001
PURPOSE To conduct a dose-escalation trial of rituximab in patients with chronic lymphocytic leukemia (CLL) to define the maximum… (More)
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Highly Cited
2000
Highly Cited
2000
PURPOSE To determine the maximum tolerated dose of single fraction radiosurgery in patients with recurrent previously irradiated… (More)
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Highly Cited
1998
Highly Cited
1998
We describe an adaptive dose escalation scheme for use in cancer phase I clinical trials. The method is fully adaptive, makes use… (More)
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