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Maximum Tolerated Dose

Known as: Maximum Tolerated Doses, Doses, Maximum Tolerated, Tolerated Doses, Maximum 
The highest dose of a drug or treatment that does not cause unacceptable side effects. The maximum tolerated dose is determined in clinical trials by… Expand
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Biosafety is the primary concern in clinical translation of nanomedicine. As an intrinsic ingredient of human blood without… Expand
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Review
2017
Review
2017
BACKGROUND This review is an update of a review of tramadol for neuropathic pain, published in 2006; updating was to bring the… Expand
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Review
2016
Review
2016
BACKGROUND For children with sickle cell anaemia and high transcranial doppler (TCD) flow velocities, regular blood transfusions… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Chimeric antigen receptor (CAR) modified T cells targeting CD19 have shown activity in case series of patients with… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Alirocumab, a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9), has been shown… Expand
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Inhibition of MEK stops cell proliferation and induces apoptosis; therefore, this enzyme is a key anticancer target… Expand
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Highly Cited
2004
Highly Cited
2004
Hydroxyurea improves hematologic parameters for children with sickle cell disease (SCD), but its long-term efficacy at maximum… Expand
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Highly Cited
2002
Highly Cited
2002
Thalidomide (Thal) can overcome drug resistance in multiple myeloma (MM) but is associated with somnolence, constipation, and… Expand
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Highly Cited
2000
Highly Cited
2000
PURPOSE To determine the maximum tolerated dose of single fraction radiosurgery in patients with recurrent previously irradiated… Expand
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Highly Cited
1998
Highly Cited
1998
We describe an adaptive dose escalation scheme for use in cancer phase I clinical trials. The method is fully adaptive, makes use… Expand
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