Matrix Metalloproteinases

Known as: Matrix Metalloprotease, Matrix Metalloproteinase, Matrix Metalloproteinases [Chemical/Ingredient] 
Matrix metalloproteinases are Zn(2+)-binding endopeptidases that degrade components of the extracellular matrix. These enzymes are implicated in… (More)

Topic mentions per year

Topic mentions per year

1973-2018
05001000150019732018

Papers overview

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Review
2016
Review
2016
Aging is a natural process characterized by the declining ability of the different organs and tissues to respond to stress… (More)
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Highly Cited
2006
Highly Cited
2006
Matrix metalloproteinases (MMPs) are zinc-endopeptidases with multifactorial actions in central nervous system (CNS) physiology… (More)
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Highly Cited
2004
Highly Cited
2004
The recent landmark Phase III clinical trial with a VEGF-specific antibody suggests that antiangiogenic therapy must be combined… (More)
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Highly Cited
2003
Highly Cited
2003
IL-8, a member of the chemokine family, has been shown to play an important role in tumor growth, angiogenesis, and metastasis… (More)
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Highly Cited
2002
Highly Cited
2002
Matrix metalloproteinases (MMPs) 9 and 2 are increased in human abdominal aortic aneurysm (AAA) tissue, but their precise role… (More)
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Highly Cited
2002
Highly Cited
2002
Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of neurodegenerative diseases and stroke. However, the… (More)
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Highly Cited
1999
Highly Cited
1999
Cardiac rupture is a fatal complication of acute myocardial infarction lacking treatment. Here, acute myocardial infarction… (More)
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Highly Cited
1998
Highly Cited
1998
During angiogenesis, endothelial cells penetrate fibrin barriers via undefined proteolytic mechanisms. We demonstrate that the… (More)
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Highly Cited
1996
Highly Cited
1996
Matrix metalloproteinases (MMPs) and interleukin 1 (IL-1) are implicated in inflammation and tissue destruction, where IL-1 is a… (More)
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Highly Cited
1994
Highly Cited
1994
Dysregulated extracellular matrix (ECM) metabolism may contribute to vascular remodeling during the development and complication… (More)
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