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Matrix Metalloproteinases

Known as: Matrix Metalloprotease, Matrix Metalloproteinase, Matrix Metalloproteinases [Chemical/Ingredient] 
Matrix metalloproteinases are Zn(2+)-binding endopeptidases that degrade components of the extracellular matrix. These enzymes are implicated in… 
National Institutes of Health

Related topics

Related topics

27 relations
AE-941Enzyme GeneHydrolysisIn Blood

Narrower (4)

CMMP matrix metalloproteinase, chickenDm1 matrix metalloproteinaseMMP-28 protein, Xenopusmatrix metalloproteinase-like protein, Gnathostoma spinigerum

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Functional Interleukin-17 Receptor A is Expressed in the Central Nervous System and Upregulated in Experimental Autoimmune Encephalomyelitisa
Interleukin-17A (IL-17A) is founding member of a novel family of inflammatory cytokines that plays a critical role in the… 
Highly Cited
2004
Highly Cited
2004
Effects of glucosamine hydrochloride on the production of prostaglandin E2, nitric oxide and metalloproteases by chondrocytes and synoviocytes in osteoarthritis.
OBJECTIVES To determine the response of glucosamine hydrochloride on chondrocytes and synoviocytes in terms of prostaglandin E2… 
Highly Cited
2003
Highly Cited
2003
Green tea catechins inhibit the cultured smooth muscle cell invasion through the basement barrier.
Highly Cited
2003
Highly Cited
2003
Synergistic cooperation between the AP‐1 and LEF‐1 transcription factors in the activation of the matrilysin promoter by the src oncogene: implications in cellular invasion
The matrix metalloprotease matrilysin is expressed in premalignant polyps and plays a key role in local invasion during the… 
Highly Cited
2002
Highly Cited
2002
A Unique Substrate Binding Mode Discriminates Membrane Type-1 Matrix Metalloproteinase from Other Matrix Metalloproteinases*
In our study, we characterized the substrate recognition properties of membrane type-1 matrix metalloproteinase (MT1-MMP; also… 
Review
2001
Review
2001
Matrix metalloproteinases and cancer.
The extracellular matrix (ECM) is a framework of proteins and proteoglycans, secreted by and surrounding stromal fibroblasts. The… 
Highly Cited
1999
Highly Cited
1999
Ovarian carcinoma regulation of matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase through beta1 integrin.
Culturing DOV 13 ovarian carcinoma cells on three-dimensional collagen lattice but not on thin-layer collagen induces processing… 
Highly Cited
1995
Highly Cited
1995
Human dermal microvascular endothelial cells produce matrix metalloproteinases in response to angiogenic factors and migration.
Matrix metalloproteinases (MMPs) are a family of inducible enzymes that degrade extracellular matrix components, allowing cells… 
Review
1993
Review
1993
Role of matrix metalloproteinases in human periodontal diseases.
Matrix metalloproteinases (MMP) are a family of proteolytic enzymes that mediate the degradation of extracellular matrix… 
Review
1990
Review
1990
Matrix metalloproteinases. A review.
Matrix metalloproteinases constitute the major proteolytic enzyme group degrading the extracellular matrix components. They are… 
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