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Matrix Metalloproteinases

Known as: Matrix Metalloprotease, Matrix Metalloproteinase, Matrix Metalloproteinases [Chemical/Ingredient] 
Matrix metalloproteinases are Zn(2+)-binding endopeptidases that degrade components of the extracellular matrix. These enzymes are implicated in… 
National Institutes of Health

Related topics

Related topics

27 relations
AE-941Enzyme GeneHydrolysisIn Blood

Narrower (4)

CMMP matrix metalloproteinase, chickenDm1 matrix metalloproteinaseMMP-28 protein, Xenopusmatrix metalloproteinase-like protein, Gnathostoma spinigerum

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Matrix metalloproteinases in tumorigenesis: an evolving paradigm
Proteases are crucial for development, tissue remodeling, and tumorigenesis. Matrix metalloproteinases (MMPs) family, in… 
Review
2006
Review
2006
Role of Matrix Metalloproteinase-7 (Matrilysin) in Human Cancer Invasion, Apoptosis, Growth, and Angiogenesis
Matrix metalloproteinase (MMP)-7, also known as matrilysin, is a “minimal domain MMP” that exhibits proteolytic activity against… 
Review
2005
Review
2005
Matrix metalloproteinases as therapeutic targets in cancer.
Degradation of extracellular matrix is crucial for malignant tumor growth, invasion, metastasis and angiogenesis. Matrix… 
Highly Cited
2003
Highly Cited
2003
Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover
Background: Pancreatic fibrosis is a characteristic feature of chronic pancreatic injury and is thought to result from a change… 
Review
2002
Review
2002
The role of matrix metalloproteinases in wound healing.
The structure, classification, function, and regulation of matrix metalloproteinases in normal and abnormal wound healing is… 
Highly Cited
2000
Highly Cited
2000
Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease
BACKGROUND/AIMS Alterations in synthesis and breakdown of extracellular matrix components are known to play a crucial role in… 
Review
1999
Review
1999
Matrix metalloproteinases in repair
During repair, many different matrix metalloproteinases are produced by multiple cell types residing in various compartments… 
Highly Cited
1998
Highly Cited
1998
The Activation and Function of Host Matrix Metalloproteinases in Dentin Matrix Breakdown in Caries Lesions
Matrix metalloproteinases (MMPs) are a family of enzymes which, in concert, are capable of degrading collagen. We investigated… 
Highly Cited
1998
Highly Cited
1998
Effect of matrix metalloproteinases activity on outflow in perfused human organ culture.
PURPOSE To test the hypothesis that extracellular matrix turnover, mediated by the matrix metalloproteinases, modulates aqueous… 
Highly Cited
1993
Highly Cited
1993
Role of Matrix Metalloproteinases in Human Periodontal Diseases.
Matrix metalloproteinases (MMP) are a family of proteolytic enzymes that mediate the degradation of extracellular matrix… 
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