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The Activity of Collagenase-1 Is Required for Keratinocyte Migration on a Type I Collagen Matrix
TLDR
It is proposed that interaction of the α2β1 integrin with dermal collagen mediates induction of collagenase-1 in keratinocytes at the onset of healing and that cleavage of Dermal collagen provides Keratinocytes with a mechanism to maintain their directionality during reepithelialization. Expand
Matrix metalloproteinases generate angiostatin: effects on neovascularization.
TLDR
It is demonstrated that purified murine and human matrix metalloproteinases generate biologically functional angiostatin from plasminogen by employing macrophages isolated from MME-deficient mice and their wild-type littermates to demonstrate that MME is required for the generation of angiOSTatin that inhibits the proliferation of human microvascular endothelial cells. Expand
IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes.
TLDR
IL-10 has a potent and unique effect upon tissue macrophages and blood monocytes by enhancing TIMP-1 production while decreasing metalloproteinase biosynthesis. Expand
Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular development.
TLDR
The potential of macrophages to directly degrade extracellular matrix via secreted metalloproteinases in a manner that differs both qualitatively and quantitatively from that of fibroblasts is confirmed. Expand
TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages.
TLDR
Results show that expression of 92-kDa gelatinase, but not its natural inhibitor TIMP-1, by human tissue-type macrophages is selectively up-regulated by proinflammatory cytokines; which suggests that these cells, when actually present in an inflammatory environment, will actively participate in the destruction of the extracellular matrix. Expand
Matrix Metalloproteinase Gelatinase B (MMP-9) Coordinates and Effects Epithelial Regeneration*
TLDR
It is concluded that gelB coordinates and effects multiple events involved in the process of epithelial regeneration, including control of cell replication, which is a novel capacity for MMPs not previously described. Expand
Matrix metalloproteinases and TIMP in acute respiratory distress syndrome.
TLDR
The high intrapulmonary levels of 92 G'ase in patients at risk and with ARDS may reflect increased turnover of extracellular matrix in acute lung injury and Interleukin-6 (IL-6) could be involved in enhanced local synthesis of TIMP. Expand
Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist.
TLDR
IL-1ra may play an important role in normal physiology or in pathophysiological states by functioning as a natural IL-1 receptor antagonist in the cell microenvironment. Expand
Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages.
TLDR
It is demonstrated that diseased aortic tissues secrete greater amounts of gelatinolytic activity than normal aorta primarily due to increased production of 92-kD gelatinase. Expand
Human 92- and 72-kilodalton type IV collagenases are elastases.
TLDR
The spectrum of human proteinases with elastolytic activity to metalloproteinases is extended and the enzymatic basis for elastase activity observed with certain cell types such as human alveolar macrophages is suggested. Expand
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