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Sulfonylureas are widely used to treat type 2 diabetes because they stimulate insulin secretion from pancreatic beta-cells. They… Expand KATP channels are a newly defined class of potassium channels based on the physical association of an ABC protein, the… Expand ATP-sensitive K+ channels couple cell metabolism to electrical activity in nerve, muscle and endocrine cells, and play important… Expand Sulfonylureas stimulate insulin secretion from pancreatic beta-cells by closing ATP-sensitive K+ (K(ATP)). The beta-cell and… Expand Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels couple the cellular metabolic state to electrical activity and… Expand MYOSIN II crossbridges interact with F-actin producing power-strokes of around 100 Å (refs 1, 2), during which the products of… Expand 1. We have measured the ATP dependence of KATP channel activity, and the effect of various metabolites on this relationship, in… Expand The products of MgATP hydrolysis bind to the nucleotide site of myosin and thus may be expected to inhibit the contraction of… Expand The kinetic mechanism for adenosine cyclic 3',5'-monophosphate dependent protein kinase was determined from initial velocity… Expand 1. The forward and reverse reactions catalysed by ATP-creatine phosphotransferase have been studied kinetically at pH8.0 in the… Expand