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MYK-461
National Institutes of Health
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Related topics
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3 relations
Broader (2)
Benzylamines
Uracil
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations
A. Sparrow
,
K. Sievert
,
+8 authors
Matthew J. Daniels
Circulation Research
2019
Corpus ID: 73419247
Rationale: Subcellular Ca2+ indicators have yet to be developed for the myofilament where disease mutation or small molecules may…
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2018
2018
REDUCTION IN LEFT VENTRICULAR OUTFLOW TRACT GRADIENT WITH MAVACAMTEN (MYK-461) IN SYMPTOMATIC OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY PATIENTS (PIONEER-HCM)
D. Jacoby
,
S. Lester
,
+5 authors
S. Heitner
2018
Corpus ID: 79576432
2018
2018
Abstract 17067: MAVERICK-HCM: Phase 2 Randomized, Multi-Center, Double-Blind, Placebo-Controlled Concentration-Guided Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Non-Obstructive…
S. Heitner
,
Andrew Wang
,
+5 authors
Carolyn Y. Ho
Circulation
2018
Corpus ID: 216869946
Introduction: Hypertrophic cardiomyopathy (HCM) carries substantial lifelong morbidity. Mutations in sarcomeric proteins that…
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2018
2018
Abstract 16466: EXPLORER-HCM: Phase 3 Randomized, Multi-Center, Double-Blind, Placebo-Controlled Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic…
I. Olivotto
,
Carolyn Y. Ho
,
+9 authors
S. Heitner
2018
Corpus ID: 216817038
Introduction: Hypertrophic cardiomyopathy, carries substantial lifelong morbidity, often associated with dynamic left ventricular…
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Highly Cited
2017
Highly Cited
2017
A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle
Raja Kawas
,
R. Anderson
,
Sadie R. Bartholomew Ingle
,
Yonghong Song
,
A. Sran
,
Hector M. Rodriguez
Journal of Biological Chemistry
2017
Corpus ID: 29822931
Mavacamten, formerly known as MYK-461 is a recently discovered novel small-molecule modulator of cardiac myosin that targets the…
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2017
2017
Abstract 20593: In vivo Cardiac Effects of Mavacamten (MYK-461): Evidence for Negative Inotropy and Improved Compliance
C. D. Rio
,
Y. Ueyama
,
+7 authors
Eric M. Green
2017
Corpus ID: 81149007
Background: Hypertrophic cardiomyopathy (HCM) is a heritable cardiac disease characterized by hyper-contractility and impaired…
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Review
2017
Review
2017
Therapeutic Strategies Targeting Inherited Cardiomyopathies
K. Varian
,
W. H. Wilson Tang
Current Heart Failure Reports
2017
Corpus ID: 13262202
Purpose of ReviewCardiomyopathies due to genetic mutations are a heterogeneous group of disorders that comprise diseases of…
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Highly Cited
2016
Highly Cited
2016
A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy
J. Stern
,
S. Markova
,
+5 authors
S. Harris
PLoS ONE
2016
Corpus ID: 12181966
Hypertrophic cardiomyopathy (HCM) is an inherited disease of the heart muscle characterized by otherwise unexplained thickening…
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