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MX1 gene

Known as: Myxovirus (Influenza Virus) Resistance 1, Interferon-Inducible Protein p78 (Mouse) Gene, INTERFERON-INDUCIBLE PROTEIN p78, MYXOVIRUS RESISTANCE 1, MOUSE, HOMOLOG OF 
This gene plays a role in GTP hydrolysis, interferon signaling and apoptosis.
National Institutes of Health

Related topics

Related topics

8 relations
Antiviral ResponseApoptosisGTP BindingHydrolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Vaccination with virus-like particles protects mice from lethal infection of Rift Valley Fever Virus.
Highly Cited
2007
Highly Cited
2007
Development and validation of a real time PCR-based bioassay for quantification of neutralizing antibodies against human interferon-beta.
Highly Cited
2005
Highly Cited
2005
Hepatitis C virus core protein down-regulates transcription of interferon-induced antiviral genes.
BACKGROUND Hepatitis C virus (HCV) proteins interfere with the interferon (IFN)-alpha-induced Jak/signal transducer and activator… 
Highly Cited
2004
Highly Cited
2004
Endogenous IFN-alpha production by plasmacytoid dendritic cells exerts an antiviral effect on thymic HIV-1 infection.
Plasmacytoid dendritic cells (pDC) are the principal producers of IFN-alpha in response to viral infection. Because pDC are… 
Highly Cited
2000
Highly Cited
2000
Cloning of an Mx cDNA from Atlantic halibut (Hippoglossus hippoglossus) and characterization of Mx mRNA expression in response to double-stranded RNA or infectious pancreatic necrosis virus.
Mx proteins are GTPases that are specifically induced by type I interferons (IFN) in vertebrates. Some mammalian Mx proteins have… 
Highly Cited
2000
Highly Cited
2000
A Monomeric GTPase-Negative MxA Mutant with Antiviral Activity
ABSTRACT MxA is a large, interferon-induced GTPase with antiviral activity against RNA viruses. It forms large oligomers, but… 
Highly Cited
1998
Highly Cited
1998
A novel bioassay for the determination of neutralizing antibodies to IFN-beta1b.
We have adapted the new MxA gene-induction bioassay to measure neutralizing antibodies to interferon-beta1b (IFN-beta1b, the… 
Highly Cited
1998
Highly Cited
1998
Domains Mediating Intramolecular Folding and Oligomerization of MxA GTPase*
MxA is an interferon-induced GTPase of human cells that inhibits the multiplication of several RNA viruses by a still poorly… 
Highly Cited
1995
Highly Cited
1995
Unexpected Structural Requirements for GTPase Activity of the Interferon-induced MxA Protein(*)
MxA is an interferon-induced 76-kDa GTPase that inhibits the multiplication of several RNA viruses. Deleting seven amino acids… 
Highly Cited
1993
Highly Cited
1993
MxA-dependent inhibition of measles virus glycoprotein synthesis in a stably transfected human monocytic cell line
The alpha/beta (type I) interferon-inducible human MxA protein confers resistance to vesicular stomatitis virus (VSV) and… 
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