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MTR protein, human

Known as: MS, 5-Methyltetrahydrofolate--Homocysteine Methyltransferase, MTR 
Methionine synthase (1265 aa, ~141 kDa) is encoded by the human MTR gene. This protein plays a role in the methylation of homocysteine.
National Institutes of Health

Related topics

Related topics

10 relations

Broader (2)

5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseVitamin B12-Dependent Methionine Synthase
Amino Acid BiosynthesisCytoplasmic matrixEnzyme GeneMTR gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
The MTR 2756A>G polymorphism and maternal risk of birth of a child with Down syndrome: a case–control study and a meta-analysis
Methionine synthase (MTR) is required for the conversion of homocysteine (hcy) to methionine in the one-carbon metabolic pathway… 
2010
2010
Reductive cleavage mechanism of Co-C bond in cobalamin-dependent methionine synthase.
The key step in the catalytic cycle of methionine synthase (MetH) is the transfer of a methyl group from the methylcobalamin… 
2008
2008
Spectroscopic study of the cobalamin-dependent methionine synthase in the activation conformation: effects of the Y1139 residue and S-adenosylmethionine on the B12 cofactor.
The cobalamin-dependent methionine synthase (MetH) from Escherichia coli is a modular enzyme that catalyzes a methyl group… 
2007
2007
Acute Methotrexate-Induced Encephalopathy - Causal Relation to Homozygous Allelic State for MTR c.2756A>G (D919G)?
Abstract Methotrexate (MTX) is widely used in the treatment of hematological diseases. The typical side-effects of high-dose MTX… 
Highly Cited
2001
Highly Cited
2001
Genetic Defects as Important Factors for Moderate Hyperhomocysteinemia
Abstract The genes for the enzymes methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS), methionine synthase… 
1999
1999
Methanol:coenzyme M methyltransferase from Methanosarcina barkeri -- substitution of the corrinoid harbouring subunit MtaC by free cob(I)alamin.
Methyl-coenzyme M formation from coenzyme M and methanol in Methanosarcina barkeri is catalysed by an enzyme system composed of… 
1997
1997
Changes in protonation associated with substrate binding and Cob(I)alamin formation in cobalamin-dependent methionine synthase.
Methionine synthase catalyzes the transfer of a methyl group from methylcobalamin enzyme to homocysteine, generating methionine… 
1993
1993
Electrospray mass spectrometric analysis of the domains of a large enzyme: observation of the occupied cobalamin-binding domain and redefinition of the carboxyl terminus of methionine synthase.
Cobalamin-dependent methionine synthase from Escherichia coli catalyzes the methylation of homocysteine to form methionine, using… 
Highly Cited
1991
Highly Cited
1991
Isolation, cloning, mapping, and nucleotide sequencing of the gene encoding flavodoxin in Escherichia coli
The flavodoxins constitute a highly conserved family of small, acidic electron transfer proteins with flavin mononucleotide… 
1972
1972
Regulation of C metabolism by L-methionine in Saccharomyces cerevisiae.
1. The concentrations of folate derivatives in aerobic cultures of Saccharomyces cerevisiae (A.T.C.C. 9763) were determined by… 
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