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MS-377

Known as: MS 377 
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Novel Sigma-1 receptor antagonists: from opioids to small molecules: what is new?
Sigma-1 (σ1) receptor has been identified as a chaperone protein that interacts with other proteins, such as N-methyl-D-aspartate… Expand
2002
2002
MS-377, a selective sigma receptor ligand, indirectly blocks the action of PCP in the N-methyl-D-aspartate receptor ion-channel complex in primary cultured rat neuronal cells.
MS-377 ((R)-(+)-1-(4-chlorophenyl)-3-[4-(2-methoxyethyl)piperazin-1-yl]methyl-2-pyrrolidinone L-tartrate) is a antipsychotic… Expand
2002
2002
Inhibition by sigma receptor ligand, MS-377, of N-methyl-D-aspartate-induced currents in dopamine neurons of the rat ventral tegmental area
Abstract.Rationale: MS-377 [(R)-(+)-1-(4-chlorophenyl)-3-[4-(2-methoxyethyl) piperazin-1-yl]methyl-2-pyrrolidinone L-tartate] is… Expand
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2002
2002
The selective sigma ligand MS-377 attenuates the blockade by phencyclidine of NMDA-induced intracellular calcium.
The role of MS-377, a novel selective sigma1 ligand currently being developed for the treatment of schizophrenia, in modulating… Expand
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2002
2002
Effects of sigma(1) receptor ligand MS-377 on D(2) antagonists-induced behaviors.
(R)-(+)-1-(4-Chlorophenyl)-3-[4-(2-methoxyethyl)piperazin-1-yl]methyl-2-pyrrolidinone L-tartrate (MS-377) is a novel… Expand
2001
2001
MS-377, a novel selective sigma(1) receptor ligand, reverses phencyclidine-induced release of dopamine and serotonin in rat brain.
A novel selective sigma(1) receptor ligand, (R)-(+)-1-(4-chlorophenyl)-3-[4-(2-methoxyethyl)piperazin-1-yl]methyl-2-pyrrolidinone… Expand
2001
2001
Effects of a novel, selective, σ1-ligand, MS-377, on phencyclidine-induced behaviour
Abstract. Phencyclidine (PCP)-induced head-weaving is inhibited by a novel selective σ1-ligand, (R)-(+)-1-(4-chlorophenyl)-3-[4… Expand
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2000
2000
Involvement of sigma 1 receptors in methamphetamine-induced behavioral sensitization in rats.
MS-377 is a novel selective sigma(1) ligand, currently being developed for the treatment of schizophrenia. In the present study… Expand
2000
2000
Effects of sigma(1) receptor ligand, MS-377 on apomorphine- or phencyclidine-induced disruption of prepulse inhibition of acoustic startle in rats.
To evaluate the antipsychotic property of a sigma(1) receptor ligand, (R)-(+)-1-(4-chlorophenyl)-3-¿4-(2-methoxyethyl)piperazin-1… Expand
1999
1999
Pharmacological profile of MS-377, a novel antipsychotic agent with selective affinity for σ receptors
Abstract Rationale: MS-377 ((R)-(+)-1-(4-chlorophenyl)-3-[4-(2-methoxyethyl)piperazin-1-yl]methyl-2-pyrrolidinone l-tartrate) was… Expand
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