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MPL NP_005364.1:p.W515L

Known as: MPL p.Trp515Leu, MPL NP_005364.1:p.Trp515Leu, TPO-R W515L 
A change in the amino acid residue at position 515 in the thrombopoietin receptor protein where tryptophan has been replaced by leucine.
National Institutes of Health

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MPL Gene MutationMPL NP_005364.1:p.W515K

Papers overview

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2017
2017
ANP32A dysregulation contributes to abnormal megakaryopoiesis in acute megakaryoblastic leukemia
Acute megakaryoblastic leukemia (AMKL) is a rare type of leukemia characterized by indefinite proliferation of megakaryocytes… 
2016
2016
MPL W515L expression induces TGFβ secretion and leads to an increase in chemokinesis via phosphorylation of THOC5
The thrombopoietin receptor (MPL) has been shown to be mutated (MPL W515L) in myelofibrosis and thrombocytosis yet new approaches… 
2012
2012
Genetic resistance to JAK 2 enzymatic inhibitors is overcome by HSP 90 inhibition
The Rockefeller University Press $30.00 J. Exp. Med. Vol. 209 No. 2 259-273 www.jem.org/cgi/doi/10.1084/jem.20111694 259 Janus… 
2010
2010
Molecular mechanisms associated with leukemic transformation of MPL-mutant myeloproliferative neoplasms
Somatic activating mutations in MPL, the thrombopoietin receptor, occur in the myeloproliferative neoplasms, although virtually… 
2010
2010
JAK2 V617F and MPL W515L/K mutations in Korean patients with essential thrombocythemia.
JAK2 V617F and MPL W515L/K mutations have been reported in approximately 50% and 5% of the patients with essential… 
2009
2009
MPL W515L/K mutations in 343 Chinese adults with JAK2V617F mutation‐negative chronic myeloproliferative disorders detected by a newly developed RQ‐PCR based on TaqMan MGB probes
Acquired mutations in the juxtamembrane region of MPL (W515L or W515K), the receptor for thrombopoietin, have been reported in… 
2009
2009
Acquired resistance to interferon alpha therapy associated with homozygous MPL‐W515L mutation and chromosome 20q deletion in primary myelofibrosis
To the Editor: A number of somatic mutations have been identified in myeloproliferative neoplasms (MPN) in the past few years… 
2008
2008
MPL W515L mutation in Chinese patients with myeloproliferative diseases
As JAK2 V617F, MPL W515L is a novel acquired mutation that induces constitutive cytokine-independent activation of the JAK-STAT… 
2006
2006
The key residues in the immunodominant region 353-363 of human thyroid peroxidase were identified.
Auto-antibodies (aAbs) to thyroid peroxidase (TPO) interact with a restricted immunodominant region (IDR) divided into two… 
1998
1998
Identification of Functionally Important Residues of Human Thrombopoietin*
Thrombopoietin (TPO) is a megakaryocyte growth and differentiation factor. It consists of a characteristic two domain structure… 
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