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MPL NP_005364.1:p.W515K

Known as: c-MPL p.Trp515Lys, TPO-R W515L, Proto-Oncogene c-Mpl Trp515Lys 
A change in the amino acid residue at position 515 in the thrombopoietin receptor protein where tryptophan has been replaced by lysine.
National Institutes of Health

Related topics

Related topics

3 relations
MPL Gene MutationMPL NM_005373.2:c.1543_1544delTGinsAAMPL NP_005364.1:p.W515L

Papers overview

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2020
2020
Genetic analysis of bcr-abl negative chronic myeloproliferative diseases at initial diagnosis and their clinical effects: A single center experience
Amac: Bu calismanin amaci, bcr-abl negatif kronik miyeloproliferatif hastalik tanisi alan hastalarin tani aninda JAK2 V617F… 
2018
2018
[Mutation Rate and Clinical Characteristics of CALR, JAK2 V617F and MPL W515K Genes in Patients With Primary Thrombocythemia].
OBJECTIVE To analyze the mutation rate and clinical characteristics of CALR, MPL W515K and JAK2 V617F genes in patients with… 
2018
2018
Characteristics of myeloproliferative neoplasms in patients exposed to ionizing radiation following the Chernobyl nuclear accident
Myeloproliferative neoplasms (MPNs) driver mutations are usually found in JAK2, MPL, and CALR genes; however, 10%‐15% of cases… 
Review
2017
Review
2017
Aplastic Anemia and Eltrombopag
Aplastic anemia which was once considered as rare and invariably fatal disease. Over the years the understanding of its… 
2015
2015
[CALR gene mutation detection and clinical observation of 150 essential thrombocythemia patients].
OBJECTIVE To explore the prevalence of CARL gene mutations and the mutation types in patients with essential thrombocythemia (ET… 
Review
2014
Review
2014
Screening of JAK2 V617F and MPL W515 K/L negative essential thrombocythaemia patients for mutations in SESN2, DNAJC17, ST13, TOP1MT, and NTRK1
Essential thrombocythaemia (ET) is a myeloproliferative neoplasm characterized by a sustained elevation of the platelet count and… 
2009
2009
MPL W515L/K mutations in 343 Chinese adults with JAK2V617F mutation‐negative chronic myeloproliferative disorders detected by a newly developed RQ‐PCR based on TaqMan MGB probes
Acquired mutations in the juxtamembrane region of MPL (W515L or W515K), the receptor for thrombopoietin, have been reported in… 
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