Skip to search formSkip to main contentSkip to account menu

MORAb-004

Known as: Anti-Endosialin Monoclonal Antibody MORAb-004 
A humanized IgG1 monoclonal antibody directed against human endosialin/TEM1 (tumor endothelial marker;CD248) with potential anti-angiogenic and… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Antibodies, Monoclonal, Humanized
antigen binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Phase 1 trial of ontuxizumab (MORAb‐004) in children with relapsed or refractory solid tumors: A report from the Children's Oncology Group Phase 1 Pilot Consortium (ADVL1213)
Ontuxizumab is a humanized IgG monoclonal antibody that targets the cell‐surface glycoprotein endosialin (tumor endothelial… 
2016
2016
Novel antibody probes for the characterization of endosialin/TEM-1
Endosialin (Tumor Endothelial Marker-1 (TEM-1), CD248) is primarily expressed on pericytes of tumor-associated microvasculature… 
2016
2016
Development of 89Zr-Ontuxizumab for in vivo TEM-1/endosialin PET applications
Purpose The complexity of sarcoma has led to the need for patient selection via in vivo biomarkers. Tumor endothelial marker-1… 
2015
2015
Phase I trial of ontuxizumab (MORAb-004) in children with relapsed or refractory solid tumors: A Children’s Oncology Group Study.
10036 Background: Ontuxizumab is a humanized IgG mAb that targets the cell-surface glycoprotein endosialin (TEM-1/CD248… 
2015
2015
A study of the safety and efficacy of the combination of gemcitabine and docetaxel with ontuxizumab (MORAb-004) in metastatic soft tissue sarcoma.
TPS10577 Background: Ontuxizumab is a humanized immunoglobulin G-1-kappa monoclonal antibody (mAb) that is the first clinical… 
2012
2012
Abstract 4410: Neutralizing Endosialin antibody, MORAb-004, enhances efficacy of TAXOTERE in a metastatic melanoma model
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Endosialin/Tumor Endothelial Marker-1 (TEM1) is a… 
2012
2012
A first-in-human phase I study of MORAb-004 (M4), a humanized monoclonal antibody recognizing endosialin (TEM-1), in patients with solid tumors.
3016 Background: Endosialin (TEM-1) is a membrane glycoprotein on the cell surface of activated mesenchymal cells (e.g. pericytes… 
2011
2011
A first-in-human phase I study of MORAb-004 (MOR4), a humanized monoclonal antibody recognizing TEM-1 (endosialin), in patients with solid tumors.
3086 Background: TEM-1 is a novel anticancer target expressed in many human malignancies and critical to tumor development. It is… 
2011
2011
Abstract 3666: Inhibition of the tumor growth and prevention of metastases with MORAb-004, a human monoclonal IgG targeting endosialin/TEM-1
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Endosialin/Tumor Endothelial Marker-1 (TEM-1) is a cell… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)