MLN 8237

Known as: Aurora A Kinase Inhibitor MLN8237, MLN-8237, MLN8237 
 
National Institutes of Health

Papers overview

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2016
2016
Aurora kinases have become an attractive target in cancer therapy due to their deregulated expression in human tumors… (More)
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2013
2013
BACKGROUND & AIMS Chronic inflammation contributes to the pathogenesis of gastric tumorigenesis. The aurora kinase A (AURKA) gene… (More)
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2013
2013
PURPOSE Despite more than 70,000 new cases of bladder cancer in the United States annually, patients with advanced disease have a… (More)
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2012
2012
PURPOSE Aurora A and B are oncogenic serine/threonine kinases that regulate mitosis. Overexpression of Auroras promotes… (More)
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Highly Cited
2012
Highly Cited
2012
PURPOSE Aurora A kinase (AAK) is a key regulator of mitosis and a target for anticancer drug development. This phase I study… (More)
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Highly Cited
2012
Highly Cited
2012
Esophageal adenocarcinomas are poorly responsive to chemotherapeutics. This study aimed to determine the levels of Aurora kinase… (More)
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Highly Cited
2012
Highly Cited
2012
OBJECTIVES Aurora A kinase (AAK), a key mitotic regulator, is implicated in the pathogenesis of several tumors, including ovarian… (More)
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2011
2011
To gain a greater understanding of the potential of the Aurora kinase A inhibitor MLN8237 in the treatment of pediatric… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND MLN8237 is a small molecule inhibitor of Aurora Kinase A (AURKA) that is currently in early phase clinical testing… (More)
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2010
2010
The Aurora kinases regulate multiple aspects of mitotic progression, and their overexpression in diverse tumor types makes them… (More)
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