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MLL/MLLT3 Fusion Protein

Known as: MLL-MLLT3 Fusion Protein, MLL/AF9 Fusion Protein, MLL-AF9 Fusion Protein 
A fusion protein encoded by the MLL/MLLT3 fusion gene. This protein is comprised of the N-terminal half of the histone-lysine N-methyltransferase MLL… 
National Institutes of Health

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Fusion GeneMLL/MLLT3 Fusion Gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Solution NMR structure of BCoR in complex with AF9 (BCoR-AF9)
2017
2017
Leukemic Stem Cells Co-Opt Normal Bone Marrow Niches As a Source of Energy and Antioxidant Defence
Modulation of oxidative stress as well as metabolic adjustments are key aspects in cancer stem cell-derived diseases, such as… 
Review
2017
Review
2017
Many Roads Lead to snoRNAs: The Ever-Expanding Universe of Non-Coding RNAs in Acute Myeloid Leukemia
Stefan Fröhling National Center for Tumor Diseases Heidelberg, German Cancer Research Center, Heidelberg University Hospital… 
Review
2015
Review
2015
Epigenetics of epithelial Na(+) channel-dependent sodium uptake and blood pressure regulation.
The epithelial Na(+) channel (ENaC) consists of α, β, γ subunits. Its expression and function are regulated by aldosterone at… 
2015
2015
Solution NMR structure of Dot1L in complex with AF9 (Dot1L-AF9).
2013
2013
Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase αENaC transcription.
Aldosterone is a major regulator of Na(+) absorption and acts by activating the mineralocorticoid receptor (MR) to stimulate the… 
2012
2012
Genetic Models Demonstrate a Requirement of MEIS1 in Survival of MLL-AF9 Leukemia
Abstract 120 MEIS1 is highly expressed in several leukemias, particularly those associated with MLL-translocations. Over… 
2012
2012
Cancer Therapy : Preclinical Antibody-Dependent Cell-Mediated Cytotoxicity Overcomes NKCellResistance in MLL-RearrangedLeukemiaExpressing Inhibitory KIR Ligands but not Activating Ligands
Purpose: Leukemias with MLL gene rearrangement are associated with a poor prognosis. Natural killer (NK) cell therapy is a… 
Highly Cited
2006
Highly Cited
2006
Dot1a-AF9 Complex Mediates Histone H3 Lys-79 Hypermethylation and Repression of ENaCα in an Aldosterone-sensitive Manner*
Aldosterone is a major regulator of epithelial Na+ absorption and acts in large part through induction of the epithelial Na… 
1995
1995
Kinetics of micelle formation of carboxymethylated surfactant in aqueous solutions
The kinetics of micelle formation of the binary mixture of the ionic and nonionic surfactants-- carboxymethylated neonol AF9-6CM… 
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