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MLKL gene

Known as: MLKL, mixed lineage kinase domain-like, FLJ34389 
National Institutes of Health

Related topics

Related topics

1 relation
mitogen-activated protein kinase kinase kinase 11

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL.
Highly Cited
2018
Highly Cited
2018
NAD+ Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis.
Highly Cited
2018
Highly Cited
2018
Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis
Necroptotic signaling converges in the assembly of a cytosolic signaling platform, the necrosome, with the activation of its… 
Highly Cited
2018
Highly Cited
2018
TWEAK and RIPK1 mediate a second wave of cell death during AKI
Significance Acute kidney injury (AKI) has a mortality of 50%. There is no satisfactory therapy and the incidence is increasing… 
Highly Cited
2016
Highly Cited
2016
The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.
Highly Cited
2015
Highly Cited
2015
Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage
Staphylococcus aureus USA300 strains cause a highly inflammatory necrotizing pneumonia. The virulence of this strain has been… 
Highly Cited
2014
Highly Cited
2014
A plug release mechanism for membrane permeation by MLKL.
Highly Cited
2014
Highly Cited
2014
Necroptosis Mediates TNF-Induced Toxicity of Hippocampal Neurons
Tumor necrosis factor-α (TNF-α) is a critical proinflammatory cytokine regulating neuroinflammation. Elevated levels of TNF… 
Highly Cited
2013
Highly Cited
2013
Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome.
Highly Cited
2013
Highly Cited
2013
Structural insights into RIP3-mediated necroptotic signaling.
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