MLKL gene

Known as: MLKL, mixed lineage kinase domain-like, FLJ34389 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2012-2018
0204020122018

Papers overview

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Highly Cited
2015
Highly Cited
2015
RIPK3 and its substrate MLKL are essential for necroptosis, a lytic cell death proposed to cause inflammation via the release of… (More)
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Highly Cited
2014
Highly Cited
2014
Programmed necrotic cell death induced by the tumor necrosis factor alpha (TNF-α) family of cytokines is dependent on a kinase… (More)
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Highly Cited
2014
Highly Cited
2014
Although mixed lineage kinase domain-like (MLKL) protein has emerged as a specific and crucial protein for necroptosis induction… (More)
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Highly Cited
2014
Highly Cited
2014
Necroptosis is considered to be complementary to the classical caspase-dependent programmed cell death pathway, apoptosis. The… (More)
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2014
2014
Necroptosis is a mechanism by which cells can kill themselves that does not require caspase activity or the presence of the pro… (More)
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Highly Cited
2014
Highly Cited
2014
Mixed lineage kinase domain-like protein (MLKL) was identified to function downstream of receptor interacting protein 3 (RIP3) in… (More)
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2014
2014
The receptor-interacting kinase-3 (RIP3) and its downstream substrate mixed lineage kinase domain-like protein (MLKL) have… (More)
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Highly Cited
2013
Highly Cited
2013
Mixed lineage kinase domain-like (MLKL) is a component of the "necrosome," the multiprotein complex that triggers tumor necrosis… (More)
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Highly Cited
2013
Highly Cited
2013
Receptor interacting protein 3 (RIP3) is a protein kinase essential for TNF-induced necroptosis. Phosphorylation on Ser-227 in… (More)
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Highly Cited
2012
Highly Cited
2012
Tumor necrosis factor (TNF) is an important inflammatory cytokine and induces many cellular responses, including inflammation… (More)
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