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ML3000

 
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
We synthesized and evaluated inhibitors for the microsomal prostaglandin E2 synthase-1 (mPGES-1), based on the arylpyrrolizine… Expand
Highly Cited
2008
Highly Cited
2008
The anti-inflammatory drug licofelone [=ML3000; 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl… Expand
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2008
2008
Objective: To find previously unknown properties of ML3000, a competitive inhibitor of the cyclooxygenase and the lipoxygenase… Expand
Highly Cited
2004
Highly Cited
2004
Since the discovery of aspirin about one century ago, many non-steroidal anti-inflammatory drugs (NSAIDs) have been used for the… Expand
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2004
2004
  • S. Laufer
  • InflammoPharmacology
  • 2004
  • Corpus ID: 25951492
NSAID management of the inflammatory process has focused on reducing the production of inflammatory prostaglandins by inhibiting… Expand
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Highly Cited
2002
Highly Cited
2002
Abstract.Objective: We examined the effects of ML3000 and several non-steroidal antiinflammatory drugs (NSAIDs) on the synthesis… Expand
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2002
2002
Abstract.Design: The studies reported were designed to evaluate the effects of ML3000 on platelet aggregation and platelet… Expand
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2002
2002
full series of preclinical studies. The GI, renal, hepatic and general tolerability was excellent. In clinical phase II and phase… Expand
Review
2001
Review
2001
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a mainstay in the treatment of inflammatory disease and are among the most… Expand
2001
2001
OBJECTIVE To search for potential new therapies to inhibit the progression of joint destruction in patients with rheumatoid… Expand