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ML3000

 
National Institutes of Health

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2009
2009
We synthesized and evaluated inhibitors for the microsomal prostaglandin E2 synthase-1 (mPGES-1), based on the arylpyrrolizine… Expand
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Highly Cited
2008
Highly Cited
2008
The anti-inflammatory drug licofelone [=ML3000; 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl… Expand
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2008
2008
2-[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid (licofelone) is a dual inhibitor of both… Expand
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2007
2007
OBJECTIVE To find previously unknown properties of ML3000, a competitive inhibitor of the cyclooxygenase and the lipoxygenase (LO… Expand
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2004
2004
Since the discovery of aspirin about one century ago, many non-steroidal anti-inflammatory drugs (NSAIDs) have been used for the… Expand
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2002
2002
Abstract.Objective: We examined the effects of ML3000 and several non-steroidal antiinflammatory drugs (NSAIDs) on the synthesis… Expand
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2002
2002
Abstract.Design: The studies reported were designed to evaluate the effects of ML3000 on platelet aggregation and platelet… Expand
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Review
2001
Review
2001
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a mainstay in the treatment of inflammatory disease and are among the most… Expand
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2001
2001
NSAID management of the inflammatory process has focused on reducing the production of inflammatory prostaglandins by inhibiting… Expand
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2001
2001
OBJECTIVE To search for potential new therapies to inhibit the progression of joint destruction in patients with rheumatoid… Expand
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