MK-8742

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2013-2017
024620132017

Papers overview

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2016
2016
Herein we describe our research efforts around the aryl and heteroaryl substitutions at the aminal carbon of the tetracyclic… (More)
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2016
2016
HCV NS5A inhibitors have demonstrated impressive in vitro potency profiles in HCV replicon assays and robust HCV RNA titer… (More)
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2016
2016
As part of an ongoing effort in NS5A inhibition at Merck we now describe our efforts for introducing substitution around the… (More)
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2016
2016
The selection of resistance-associated variants (RAVs) against single agents administered to patients chronically infected with… (More)
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Hepatitis C virus (HCV) infection is a leading cause of morbidity and mortality in patients with HIV-1. The C-EDGE CO… (More)
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Highly Cited
2015
Highly Cited
2015
BACKGROUND There is a high medical need for an interferon-free, all-oral, short-duration therapy for hepatitis C virus (HCV) that… (More)
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Both hepatitis C virus (HCV) mono-infected and HIV/HCV co-infected patients are in need of safe, effective, all-oral… (More)
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2015
2015
Elbasvir is an investigational NS5A inhibitor with in vitro activity against multiple HCV genotypes. Antiviral activity of… (More)
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2014
2014
We have previously reported the discovery of our P2-P4 macrocyclic HCV NS3/4a protease inhibitor MK-5172, which in combination… (More)
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2013
2013
The NS5A protein plays a critical role in the replication of HCV and has been the focus of numerous research efforts over the… (More)
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