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Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection
TLDR
In conclusion, noninvasive tests can accurately predict hepatic fibrosis and may reduce the need for liver biopsy in the majority of HIV/HCV‐coinfected patients.
View on Wiley
Recent epidemic of acute hepatitis C virus in HIV-positive men who have sex with men linked to high-risk sexual behaviours
TLDR
The identified co-circulating HCV lineages belong to different subtypes and genotypes, implying that rather than viral change, the epidemic is due to permucosal transmission factors that should be the focus of public health interventions.
View on Wolters Kluwer
Loss of Discrete Memory B Cell Subsets Is Associated with Impaired Immunization Responses in HIV-1 Infection and May Be a Risk Factor for Invasive Pneumococcal Disease1
TLDR
It is demonstrated that defects in B cell memory subsets are associated with impaired humoral immune responses in HIV-1 patients who are receiving antiretroviral therapy and may be a contributory factor to the increased risk of invasive pneumococcal infection observed in HIV -1 infection.
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Highly active antiretroviral therapy and the incidence of non-AIDS-defining cancers in people with HIV infection.
TLDR
Since the introduction of HAART, there has been a significantly increased risk of NADCs, which has now stabilized, and a number of factors are associated with this increased risk, including HAART use.
View on PubMed
Subgroup analyses of maraviroc in previously treated R5 HIV-1 infection.
TLDR
Subanalyses of pooled data from week 48 indicate that maraviroc provides a valuable treatment option for a wide spectrum of patients with R5 HIV-1 infection who have been treated previously.
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Impact of late diagnosis and treatment on life expectancy in people with HIV-1: UK Collaborative HIV Cohort (UK CHIC) Study
TLDR
Life expectancy in people treated for HIV infection has increased by over 15 years during 1996-2008, but is still about 13 years less than that of the UK population.
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Evidence of a large, international network of HCV transmission in HIV-positive men who have sex with men.
TLDR
An international phylogenetic study revealed a large international network of HCV transmission among HIV-positive MSM, supported by the large proportion of European MSM infected with an HCV strain co-circulating in multiple European countries, the low evolutionary distances among HCV isolates from different countries, and the trend toward increased country mixing with increasing cluster size.
View on PubMed
Evaluation of a modified commercial assay in detecting antibody to hepatitis C virus in oral fluids and dried blood spots
TLDR
Oral fluids collected by the OraSure device provide an extremely useful method to conduct public health surveillance of not only HIV, but also hepatitis C, among injecting drug users, and dried blood spot specimens may be useful for surveillance and could be employed as a first line diagnostic specimen.
View on Wiley
Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy
TLDR
It is demonstrated here ongoing virus replication in a large percentage of infected individuals on highly active anti-retroviral therapy, despite sustained undetectable levels of plasma viral RNA, has important implications for the clinical management of HIV-1-infected individuals and for the development of virus eradication strategies.
View on Nature
Clinical Features and Outcome in HIV-Associated Multicentric Castleman's Disease.
TLDR
The outlook has improved dramatically in recent years with the introduction of rituximab-based therapy and yields high overall survival rates, and HIV-associated MCD is a remitting-relapsing disease.
View on PubMed
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