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MK-639
Known as:
MK 639
, MK639
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Indinavir
Indinavir Sulfate
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2000
2000
Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors.
B. Dorsey
,
C. McDonough
,
+17 authors
J. Vacca
Journal of Medicinal Chemistry
2000
Corpus ID: 23662460
Recent results from human clinical trials have established the critical role of HIV protease inhibitors in the treatment of…
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1998
1998
Molecular mechanisms of resistance: Free energy calculations of mutation effects on inhibitor binding to HIV‐1 protease
S. Rick
,
I. Topol
,
S. Burt
,
J. Erickson
Protein Science
1998
Corpus ID: 40650892
The changes in the inhibitor binding constants due to the mutation of isoleucine to valine at position 84 of HIV‐1 protease are…
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1998
1998
An Escherichia coli Expression Assay and Screen for Human Immunodeficiency Virus Protease Variants with Decreased Susceptibility to Indinavir
L. Melnick
,
Shiow-Shong Yang
,
Rick Rossi
,
C. Zepp
,
D. Heefner
Antimicrobial Agents and Chemotherapy
1998
Corpus ID: 20235808
ABSTRACT We have developed a recombinant Escherichia coliscreening system for the rapid detection and identification of amino…
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1995
1995
Update on HIV protease inhibitors.
S. Vella
AIDS Clinical Care
1995
Corpus ID: 20633886
When HIV replicates, it forms large precursor proteins that are cleaved and processed by HIV protease to generate smaller viral…
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1995
1995
Merck protease inhibitor MK-639 -- trial cities announced.
AIDS treatment news
1995
Corpus ID: 22007593
Merck will conduct two large trials to test MK-639, a protease inhibitor. One trial is for people who have never taken AZT or…
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1995
1995
Protease inhibitor update.
R. Colvin
,
G. Haas
Common factor
1995
Corpus ID: 20625133
New clinical trial developments surrounding anti-HIV compounds, known as protease inhibitors, are discussed for the following…
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1995
1995
Future of ICC debated. Inter-Company Collaboration for AIDS Drug Development.
T. Smart
GMHC treatment issues : the Gay Men's Health…
1995
Corpus ID: 20573135
The Inter-Company Collaboration for AIDS Drug Development (ICC) was created to foster cooperation between pharmaceutical…
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1995
1995
3TC and protease inhibitors: citizen's petition asks faster approval.
AIDS treatment news
1995
Corpus ID: 37058866
Log Cabin Republicans, a gay and lesbian Republican organization, has formally petitioned the Food and Drug Administration (FDA…
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1995
1995
New trial proposed for when drugs fail.
J. James
AIDS treatment news
1995
Corpus ID: 35845198
On May 11, 1995, community AIDS representatives met with members of the Clinical Trials subcommittee of the Inter-Company…
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1995
1995
Advances in protease inhibitors.
B. Cheng
PI perspective
1995
Corpus ID: 24976364
Advances in protease inhibitor clinical studies are discussed for the following inhibitors: Merck MK-639, Abbott ABT-538…
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