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MK-1597

Known as: ACT-178882 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

CyclopropanesPyridines

Papers overview

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2014
2014
Investigation of combined CYP3A4 inductive/inhibitory properties by studying statin interactions: a model study with the renin inhibitor ACT-178882
ACT-178882, a direct renin inhibitor, was used as a model compound in an elaborate drug–drug interaction study with atorvastatin… 
2014
2014
Reply to letter: Age and sex effects on the single- and multiple-dose safety and pharmacokinetics of the new renin inhibitor ACT-178882.
2013
2013
Clinical pharmacology of single‐ and multiple‐ascending doses of ACT‐178882, a new direct renin inhibitor, and its pharmacokinetic interaction with food and midazolam
This study investigated the tolerability, safety, pharmacokinetics, and pharmacodynamics of ACT‐178882, a new direct renin… 
2013
2013
Age and sex effects on the single- and multiple-dose safety and pharmacokinetics of the new renin inhibitor ACT-178882.
AIM To investigate the effect of age and sex on the single- and multiple-dose safety and pharmacokinetics of ACT-178882, a new… 
2013
2013
Drug-Drug Interaction Study of ACT-178882, a New Renin Inhibitor, and Diltiazem in Healthy Subjects
Background and ObjectiveThe cytochrome P450 (CYP) enzyme, CYP3A4, metabolizes ACT-178882, a new direct renin inhibitor. This… 
2013
2013
Age and sex effects on the single- and multiple-dose safety and pharmacokinetics of the new rennin inhibitor ACT-178882.
2013
2013
Age and Sex Effects on the Single- and Multiple-dose Safety and Pharmacokinetics of the New Rennin Inhibitor ACT-178882
2010
2010
Piperidine-based renin inhibitors: upper chain optimization.
2010
2010
American Society for Clinical Pharmacology and Therapeutics (ASCPT)-111th annual meeting. 17-20 March 2010, Atlanta, GA, USA.
  • C. Veryard
  • IDrugs : the investigational drugs journal
  • 2010
  • Corpus ID: 29182006
The 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics, held in Atlanta, included topics… 
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