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MK 0679

Known as: MK-0679, MK-679 
National Institutes of Health

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1 relation

Broader (1)

verlukast

Papers overview

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2012
2012
Effect of selective cysteinyl leukotriene receptor antagonists on airway inflammation and matrix metalloproteinase expression in a mouse asthma model.
Highly Cited
2000
Highly Cited
2000
Priming of alveolar macrophages by leukotriene D(4): potentiation of inflammation.
Cysteinyl leukotrienes (LTs), including LTC(4), LTD(4), and LTE(4), are well known to induce bronchoconstriction and increase… 
Review
1997
Review
1997
Leukotrienes in the pathogenesis of asthma.
Asthma is a chronic inflammatory disease that is associated with widespread but variable airflow obstruction. The mechanisms that… 
1996
1996
Induction of hyperresponsiveness in human airway tiss by neutrophils — mechanism of action
Background The two main features of asthtna are bronchial hyperresponsiveness and inflammation. The inflammatory response in… 
1996
1996
Drug substance manufacture process control: application of flow injection analysis and HPLC for monitoring an enantiospecific synthesis.
Highly Cited
1993
Highly Cited
1993
The leukotriene-receptor antagonist MK-0679 blocks airway obstruction induced by inhaled lysine-aspirin in aspirin-sensitive asthmatics.
Drugs which block the action or formation of the cysteinyl leukotrienes (LTC4, LTD4 and LTE4) inhibit asthmatic responses evoked… 
Highly Cited
1993
Highly Cited
1993
Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects.
BACKGROUND--The cysteinyl leukotrienes (LTC4, LTD4, and LTE4) have been shown to mediate airway obstruction evoked by several… 
1993
1993
Acute bronchodilation with an intravenously administered leukotriene D4 antagonist, MK-679.
Descriptive studies suggest an association between the release of the cysteinyl leukotrienes and clinical asthma. To help clarify… 
1992
1992
Bronchodilator properties of an inhaled leukotriene D4 antagonist (verlukast--MK-0679) in asthmatic patients.
1991
1991
Pharmacology of the leukotriene antagonist verlukast: the (R)-enantiomer of MK-571.
Verlukast (MK-679) (3-[(3-(2-(7-chloro-2-quinolinyl)-(E)-ethenyl)phenyl)[3-(dimethylamino)- 3- oxopropyl)thio)methyl)-thio… 
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