Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

MK 0679

Known as: MK-0679, MK-679 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

verlukast

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Effect of selective cysteinyl leukotriene receptor antagonists on airway inflammation and matrix metalloproteinase expression in a mouse asthma model.
BACKGROUND Cysteinyl leukotrienes (CysLTs) play a major role in the pathogenic changes of airway inflammation in asthma treatment… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2000
2000
Priming of alveolar macrophages by leukotriene D(4): potentiation of inflammation.
Cysteinyl leukotrienes (LTs), including LTC(4), LTD(4), and LTE(4), are well known to induce bronchoconstriction and increase… Expand
Is this relevant?
Review
1997
Review
1997
Leukotrienes in the pathogenesis of asthma.
Asthma is a chronic inflammatory disease that is associated with widespread but variable airflow obstruction. The mechanisms that… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
1996
1996
Induction of hyperresponsiveness in human airway tissue by neutrophils--mechanism of action.
BACKGROUND The two main features of asthma are bronchial hyperresponsiveness and inflammation. The inflammatory response in… Expand
Is this relevant?
1995
1995
Verlukast (MK-0679) conjugation with glutathione by rat liver and kidney cytosols and excretion in the bile.
Verlukast (MK-0679) is a potent leukotriene D4 antagonist that was under development for the treatment of bronchial asthma. A… Expand
Is this relevant?
Highly Cited
1993
Highly Cited
1993
The leukotriene-receptor antagonist MK-0679 blocks airway obstruction induced by inhaled lysine-aspirin in aspirin-sensitive asthmatics.
Drugs which block the action or formation of the cysteinyl leukotrienes (LTC4, LTD4 and LTE4) inhibit asthmatic responses evoked… Expand
Is this relevant?
1993
1993
Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects.
BACKGROUND--The cysteinyl leukotrienes (LTC4, LTD4, and LTE4) have been shown to mediate airway obstruction evoked by several… Expand
Is this relevant?
Review
1993
Review
1993
Leukotriene antagonists and inhibitors as modulators of IgE-mediated reactions
ConclusionsThe biological activities of the leukotrienes and the fact that they are produced in elevated amounts in asthmatic… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
1992
1992
Bronchodilator properties of an inhaled leukotriene D4 antagonist (verlukast--MK-0679) in asthmatic patients.
The safety, tolerability and bronchodilator properties of inhaled verlukast (MK-0679), a new potent and selective LTD4-receptor… Expand
Is this relevant?
1991
1991
Pharmacology of the leukotriene antagonist verlukast: the (R)-enantiomer of MK-571.
Verlukast (MK-679) (3-[(3-(2-(7-chloro-2-quinolinyl)-(E)-ethenyl)phenyl)[3-(dimethylamino)- 3- oxopropyl)thio)methyl)-thio… Expand
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE