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MK 0679

Known as: MK-0679, MK-679 
 
National Institutes of Health

Papers overview

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2012
2012
BACKGROUND Cysteinyl leukotrienes (CysLTs) play a major role in the pathogenic changes of airway inflammation in asthma treatment… Expand
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2000
2000
Cysteinyl leukotrienes (LTs), including LTC(4), LTD(4), and LTE(4), are well known to induce bronchoconstriction and increase… Expand
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Review
1997
Review
1997
Asthma is a chronic inflammatory disease that is associated with widespread but variable airflow obstruction. The mechanisms that… Expand
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1996
1996
BACKGROUND The two main features of asthma are bronchial hyperresponsiveness and inflammation. The inflammatory response in… Expand
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1995
1995
Verlukast (MK-0679) is a potent leukotriene D4 antagonist that was under development for the treatment of bronchial asthma. A… Expand
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Highly Cited
1993
Highly Cited
1993
Drugs which block the action or formation of the cysteinyl leukotrienes (LTC4, LTD4 and LTE4) inhibit asthmatic responses evoked… Expand
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1993
1993
BACKGROUND--The cysteinyl leukotrienes (LTC4, LTD4, and LTE4) have been shown to mediate airway obstruction evoked by several… Expand
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Review
1993
Review
1993
ConclusionsThe biological activities of the leukotrienes and the fact that they are produced in elevated amounts in asthmatic… Expand
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1992
1992
The safety, tolerability and bronchodilator properties of inhaled verlukast (MK-0679), a new potent and selective LTD4-receptor… Expand
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1991
1991
Verlukast (MK-679) (3-[(3-(2-(7-chloro-2-quinolinyl)-(E)-ethenyl)phenyl)[3-(dimethylamino)- 3- oxopropyl)thio)methyl)-thio… Expand
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