Skip to search formSkip to main contentSkip to account menu

MK 0591

Known as: MK-591, MK591 compound, MK 591 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

IndolesQuiflaponQuinolines
L 686708

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1999
1999
Generation of thromboxane A2 from highly purified human sinus mast cells after immunological stimulation.
To better understand metabolites of arachidonic acid generated from human mast cells, the present study assessed the capacity of… 
1999
1999
Role of 5-lipoxygenase products in the local accumulation of neutrophils in dermal inflammation in the rabbit.
Studies were undertaken to define the role of 5-lipoxygenase (5-LO) products and, in particular, of leukotriene (LT) B4 in the… 
Review
1996
Review
1996
Antileukotriene therapy for asthma
The role of leukotrienes (LTs) in asthma is reviewed, and research to develop anti-LT agents for this condition is described… 
Review
1996
Review
1996
Antileukotriene therapy for asthma?
The role of leukotrienes (LTs) in asthma is reviewed, and research to develop anti-LT agents for this condition is described… 
Highly Cited
1995
Highly Cited
1995
The effect of MK-0591, a novel 5-lipoxygenase activating protein inhibitor, on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo.
1995
1995
Antiasthmatic effects of a leukotriene biosynthesis inhibitor (MK-0591) in allergic dogs.
Peptidoleukotrienes may be important mediators of human bronchial asthma. Accordingly, the effects of a selective leukotriene (LT… 
1995
1995
Pharmacokinetic and pharmacodynamic analysis of a novel leukotriene biosynthesis inhibitor, MK-0591, in healthy volunteers.
1. The pharmacokinetic and pharmacodynamic properties of a novel 2-indolealkanoic acid derivative (MK-0591), a potent inhibitor… 
1995
1995
Inhibition of leukotriene biosynthesis improves renal function in experimental glomerulonephritis.
1995
1995
Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis.
1994
1994
Effect of FLAP antagonist MK-0591 on leukotriene production and ozone-induced airway responses in dogs.
We used the 5-lipoxygenase-activating protein (FLAP) antagonist MK-0591 to investigate the importance of leukotrienes (LT) in… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)