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MELK gene

Known as: KIAA0175, MELK, HPK38 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Maternal embryonic leucine zipper kinase serves as a poor prognosis marker and therapeutic target in osteosarcoma
Osteosarcoma is the most common primary malignancy of bones and frequently affects young children and adolescents. There are… 
2019
2019
Maternal Embryonic Leucine Zipper Kinase (MELK), a Potential Therapeutic Target for Neuroblastoma
Maternal embryonic leucine zipper kinase (MELK) activates pathways that mediate aggressive tumor growth and therapy resistance in… 
2018
2018
Structure-based discovery of new maternal embryonic leucine zipper kinase inhibitors.
Maternal embryonic leucine zipper kinase (MELK), a serine/threonine protein kinase, has oncogenic properties and plays a key… 
2016
2016
Anti-myeloma activity of MELK inhibitor OTS167: effects on drug-resistant myeloma cells and putative myeloma stem cell replenishment of malignant plasma cells
Currently considered incurable, multiple myeloma (MM) is characterized by proliferation of malignant plasma cells (PC… 
2016
2016
Expression of Maternal Embryonic Leucine Zipper Kinase (MELK) Correlates to Malignant Potentials in Hepatocellular Carcinoma.
BACKGROUND/AIM Maternal embryonic leucine zipper kinase (MELK) is categorized as a member of AMP-activated protein kinase… 
2015
2015
Evaluation of Stem Cell Marker Expression in Canine B-Cell Lymphoma Cell Lines, B-Cell Lymphoma-generated Spheres and Primary Samples.
BACKGROUND Canine lymphoma has lately drawn focus as a model of human non-Hodgkin's lymphoma due to its spontaneous occurrence… 
2014
2014
The crystal structure of MPK38 in complex with OTSSP167, an orally administrative MELK selective inhibitor.
2014
2014
Maternal embryonic leucine zipper kinase regulates pancreatic ductal, but not β‐cell, regeneration
The maternal embryonic leucine zipper kinase (MELK) is expressed in stem/progenitor cells in some adult tissues, where it has… 
2013
2013
Cell-cycle dependent localization of MELK and its new partner RACK1 in epithelial versus mesenchyme-like cells in Xenopus embryo
Summary Maternal Embryonic Leucine zipper Kinase (MELK) was recently shown to be involved in cell division of Xenopus embryo… 
2009
2009
Methods for analysis of brain tumor stem cell and neural stem cell self-renewal.
Neural stem cells (NSC) self-renew and are multipotent, producing neurons and glia. Recent studies have shown that brain tumors… 
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